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Treatment of chronic rhinosinusitis using erythromycin phonophoresis

机译：红霉素发声治疗慢性鼻-鼻窦炎

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摘要

Bacterial biofilms have been implicated in many chronic infective diseases, including chronic rhinosinusitis (CRS). Therapeutic ultrasound enhances the breakdown of bacterial biofilms and is clinically effective in CRS treatment, while phonophoresis has also been utilized for antibiotic delivery through the skin. The objective of this case report is to describe the results of a novel treatment, erythromycin phonophoresis, in a woman with CRS. A 31-year-old woman with a 7-month history of CRS refractory to conventional medical management was treated with erythromycin phonophoresis to both maxillary sinuses. Individual sinus symptom severity was assessed and sinus CT scans were obtained both pretreatment and posttreatment. After treatment, the total sinusitis symptom score improved from 12 to 0 and the CT scan showed almost complete disease resolution. At 5-month follow-up, the patient reported sustained improvement. Erythromycin phonophoresis has potential as an effective treatment for CRS.
机译：细菌生物膜与许多慢性感染性疾病有关，包括慢性鼻-鼻窦炎（CRS）。超声治疗可增强细菌生物膜的分解作用，并且在CRS治疗中临床有效，而声透疗法也已用于通过皮肤输送抗生素。本病例报告的目的是描述患有CRS的女性新疗法红霉素发声的结果。一名对传统药物治疗无效的CRS病史为7个月的31岁妇女接受了红霉素的声固疗法治疗两个上颌窦。评估个体鼻窦症状的严重程度，并在治疗前和治疗后进行鼻窦CT扫描。治疗后，总的鼻窦炎症状评分从12改善为0，CT扫描显示疾病完全消退。在5个月的随访中，患者报告持续改善。红霉素发声可作为治疗CRS的有效方法。

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