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首页> 外文期刊>Proceedings of the Nutrition Society >Fatty acids and the immune system: from basic science to clinical applications
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Fatty acids and the immune system: from basic science to clinical applications

机译：脂肪酸与免疫系统：从基础科学到临床应用

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摘要

Over the last 25 years, the effects of fatty acids on the immune system have been characterized using in vitro, animal and human studies. Advances in fatty acid biochemistry and molecular techniques have recently suggested new mechanisms by which fatty acids could potentially modify immune responses, including modification of the organization of cellular lipids and interaction with nuclear receptors. Possibilities for the clinical applications of n-3 PUFA are now developing. The present review focuses on the hypothesis that the anti-inflammatory properties of n-3 PUFA in the arterial wall may contribute to the protective effects of n-3 PUFA in CVD, as suggested by epidemiological and secondary prevention studies. Studies are just beginning to show that dietary n-3 PUFA can be incorporated into plaque lipid in human subjects, where they may influence the morphology and stability of the atherosclerotic lesion.
机译：在过去的25年中，已通过体外，动物和人体研究表征了脂肪酸对免疫系统的影响。脂肪酸生物化学和分子技术的进步最近提出了新的机制，脂肪酸可以通过这种机制来改变免疫反应，包括改变细胞脂质的组织以及与核受体的相互作用。 n-3 PUFA的临床应用可能性正在发展。如流行病学和二级预防研究所述，本综述主要围绕以下假设：动脉壁n-3 PUFA的抗炎特性可能有助于n-3 PUFA在CVD中的保护作用。研究刚刚开始表明，饮食中的n-3 PUFA可掺入人类受试者的斑块脂质中，在那里它们可能会影响动脉粥样硬化病变的形态和稳定性。

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