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首页> 外文期刊>Biochemistry and Cell Biology >Long-range histone acetylation: biological significance, structural implications, and mechanisms
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Long-range histone acetylation: biological significance, structural implications, and mechanisms

机译：远程组蛋白乙酰化：生物学意义，结构意义和机制。

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Genomic characterization of various euchromatic regions in higher eukaryotes has revealed that domain-wide hyperacetylation (over several kb) occurs at a range of loci, including individual genes, gene family clusters, compound clusters, and more general clusters of unrelated genes. Patterns of long-range histone hyperacetylation are strictly conserved within each unique cellular system studied and they reflect biological variability in gene regulation. Domain-wide histone acetylation consists generally of nonuniform peaks of enriched hyperacetylation of specific core histones, histone isoforms, and (or) histone variants against a backdrop of nonspecific acetylation across the domain in question. Here we review the characteristics of long-range histone acetylation in some higher eukaryotes and draw special attention to recent literature on the multiple effects that histone hyperacetylation has on chromatin’s structural integrity and how they affect transcription. These include the thermal, ionic, cumulative, and isoform-specific (H4 K16) consequences of acetylation that result in a more dynamic core complex and chromatin fiber.
机译：高等真核生物中各个常染色体区域的基因组学表征显示，整个域的超乙酰化（超过几kb）发生在一系列基因座上，包括单个基因，基因家族簇，化合物簇以及更普遍的无关基因簇。远程组蛋白超乙酰化的模式在每个研究的独特细胞系统中都严格保留，并且反映了基因调控中的生物学变异性。整个域范围内的组蛋白乙酰化通常由特定核心组蛋白，组蛋白同工型和（或）组蛋白变体在整个域中非特异性乙酰化的背景下富集的超乙酰化的不均匀峰组成。在这里，我们回顾了一些高级真核生物中长距离组蛋白乙酰化的特征，并特别关注了有关组蛋白高乙酰化对染色质结构完整性及其如何影响转录的多重影响的最新文献。这些包括乙酰化的热，离子，累积和同工型特异性（H4 K16）后果，从而使核心复合物和染色质纤维更具活力。

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