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首页> 外文期刊>Proceedings of the Institution of Mechanical Engineers, Part H. Journal of Engineering in Medicine >A study of the relationship between process conditions and mechanical strength of mineralized red algae in the preparation of a marine-derived bone void filler
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A study of the relationship between process conditions and mechanical strength of mineralized red algae in the preparation of a marine-derived bone void filler

机译：制备海洋源性骨空隙填充剂过程中矿化红藻力学条件与机械强度之间关系的研究

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摘要

Bone void fillers that can enhance biological function to augment skeletal repair have significant therapeutic potential in bone replacement surgery. This work focuses on the development of a unique microporous (0.5-10 μm) marine-derived calcium phosphate bioceramic granule. It was prepared from Corallina officinalis, a mineralized red alga, using a novel manufacturing process. This involved thermal processing, followed by a low pressuretemperature chemical synthesis reaction. The study found that the ability to maintain the unique algal morphology was dependent on the thermal processing conditions. This study investigates the effect of thermal heat treatment on the physiochemical properties of the alga. Thermogravimetric analysis was used to monitor its thermal decomposition. The resultant thermograms indicated the presence of a residual organic phase at temperatures below 500°C and an irreversible solid-state phase transition from mg-rich-calcite to calcium oxide at temperatures over 850°C. Algae and synthetic calcite were evaluated following heat treatment in an aircirculating furnace at temperatures ranging from 400 to 800°C. The highest levels of mass loss occurred between 400-500°C and 700-800℃, which were attributed to the organic and carbonate decomposition respectively. The changes in mechanical strength were quantified using a simple mechanical test, which measured the bulk compressive strength of the algae. The mechanical test used may provide a useful evaluation of the compressive properties of similar bone void fillers that are in granular form. The study concluded that soak temperatures in the range of 600 to 700℃ provided the optimum physiochemical properties as a precursor to conversion to hydroxyapatite (HA). At these temperatures, a partial phase transition to calcium oxide occurred and the original skeletal morphology of the alga remained intact.
机译：可以增强生物学功能以增强骨骼修复的骨空隙填充剂在骨替代手术中具有巨大的治疗潜力。这项工作专注于开发独特的微孔（0.5-10μm）海洋来源的磷酸钙生物陶瓷颗粒。它是由Corallina officinalis（一种矿化的红藻）采用新颖的制造工艺制成的。这涉及热处理，然后进行低压温度化学合成反应。研究发现，维持独特藻类形态的能力取决于热处理条件。这项研究调查了热处理对藻类理化性质的影响。热重分析用于监测其热分解。所得的热谱图表明在低于500°C的温度下存在残留的有机相，并且在超过850°C的温度下从富镁方解石到氧化钙发生不可逆的固态相变。在空气循环炉中在400至800°C的温度下进行热处理后，评估了藻类和合成方解石。最高的质量损失发生在400-500℃和700-800℃之间，这分别归因于有机物和碳酸盐的分解。使用简单的机械测试对机械强度的变化进行定量，该机械测试测量了藻类的整体抗压强度。所使用的机械测试可以对类似的颗粒状骨空隙填充物的压缩特性提供有用的评估。研究得出的结论是，浸泡温度在600至700℃范围内可提供最佳的物理化学性质，作为转化为羟基磷灰石（HA）的前身。在这些温度下，发生部分相转变为氧化钙，藻类的原始骨骼形态保持完整。

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