...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biomaterials >Neointima formation on vascular elastic laminae and collagen matrices scaffolds implanted in the rat aortae
【24h】

Neointima formation on vascular elastic laminae and collagen matrices scaffolds implanted in the rat aortae

机译：在大鼠主动脉中植入的血管弹性层和胶原基质支架上的新内膜形成

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Synthetic polymers, including polytetrafluoroethylene and Dacron, and biomatrix proteins, including collagen and fibrin, have been used for the construction of vascular substitutes. However, these materials induce inflammatory reactions, contributing to thrombosis, smooth muscle cell (SMC) proliferation, and neointima formation, processes leading to the failure of vascular substitutes. Thus, a pressing issue in vascular reconstruction is to construct vascular substitutes with surface materials that are inflammation-ressistant. Here, we demonstrate that the vascular elastic laminae exhibit such a property. Aortic specimens from donor rats were treated with 0.1 M NaOH for various times, resulting in elastic lamina-collagen matrix scaffolds with and without the basal lamina. Matrix scaffolds were implanted into the host aorta with three different surface materials, including the elastic lamina, basal lamina, and adventitial collagen, and observed for leukocyte adhesion, endothelial migration, cell proliferation, and neointimal formation on these surfaces. It was found that the elastic lamina was associated with significantly lower leukocyte adhesion, BrdU incorporation, and neointima formation than the basal lamina and adventitial collagen, while the migration of endothelial cells was comparable on all three surfaces. The adventitial collagen matrix was associated with leukocyte infiltration from blood and subsequent SMC migration from the host aorta, whereas the elastic laminae were resistant to such processes. The morphology of the implanted elastic laminae appeared normal at all times. These observations suggest that the vascular elastic laminae exhibit inflammation-resistant properties and inhibit SMC mitogenic activities compared with collagen-containing matrices and may be considered a potential surface material for vascular reconstruction. (C) 2003 Elsevier Ltd. All rights reserved. [References: 62]
机译：包括聚四氟乙烯和涤纶的合成聚合物，以及包括胶原蛋白和血纤蛋白的生物基质蛋白已被用于构建血管替代物。但是，这些物质会引起炎症反应，从而导致血栓形成，平滑肌细胞（SMC）增殖和新内膜形成，从而导致血管替代物失效。因此，血管重建中的紧迫问题是用具有抗炎作用的表面材料构建血管替代物。在这里，我们证明了血管弹性薄片表现出这种特性。用0.1 M NaOH对供体大鼠的主动脉标本进行不同时间的处理，形成带有或不带有基底层的弹性层状胶原蛋白基质支架。将基质支架植入具有三种不同表面材料的宿主主动脉中，包括弹性层板，基底层板和外膜胶原，并观察这些表面上的白细胞粘附，内皮迁移，细胞增殖和新内膜形成。发现弹性薄层与白细胞粘附，BrdU掺入和新内膜形成明显低于基底薄层和外膜胶原蛋白，而内皮细胞的迁移在所有三个表面上均相当。外膜胶原蛋白基质与白细胞从血液中浸润以及随后的SMC从宿主主动脉中迁移有关，而弹性层对这种过程具有抵抗力。植入的弹性薄片的形态在任何时候都看起来是正常的。这些观察结果表明，与含胶原蛋白的基质相比，血管弹性薄片具有抗炎特性并抑制SMC有丝分裂活性，并且可以认为是血管重建的潜在表面材料。 （C）2003 Elsevier Ltd.保留所有权利。 [参考：62]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号