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首页> 外文期刊>Progress in Cardiovascular Diseases >The clinical use of angiotensin-converting enzyme inhibitors.
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The clinical use of angiotensin-converting enzyme inhibitors.

机译:血管紧张素转化酶抑制剂的临床应用。

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摘要

Through an integrative understanding of cardiovascular pathophysiologic characteristics at the multiorgan level, significant achievements in cardiovascular therapeutics have been achieved and enabled the rationale design and development of drugs such as the angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs). In this article, we present a detailed review of the physiologic features of the renin-angiotensin-aldosterone system (RAAS), ACE inhibitors and ARB clinical pharmacologic characteristics, and specific diseases in which they are considered to be the standard of the care as supported by important clinical trial data. It is envisioned that an updated and detailed understanding of ACE inhibitors and ARBs will facilitate their successful use in the treatment of heart failure, myocardial infarction, hypertension, renal failure, and diabetic nephropathy.
机译:通过对多器官水平的心血管病理生理特征的综合理解,心血管治疗取得了显著成就,并使血管紧张素转换酶(ACE)抑制剂和血管紧张素受体阻滞剂(ARB)等药物的理论设计和开发成为可能。在本文中,我们对肾素-血管紧张素-醛固酮系统(RAAS),ACEI抑制剂和ARB临床药理特性以及特定疾病的详细生理学综述,其中它们被视为支持的护理标准通过重要的临床试验数据。可以预见的是,对ACE抑制剂和ARB的更新和详细的了解将有助于它们成功地用于治疗心力衰竭,心肌梗塞,高血压,肾衰竭和糖尿病性肾病。

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