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首页> 外文期刊>Psychiatry Research. Neuroimaging >Age effect on subcortical structures in healthy adults
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Age effect on subcortical structures in healthy adults

机译：年龄对健康成年人皮层下结构的影响

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摘要

Cross-sectional age effects in normal control volunteers were investigated using magnetic resonance imaging in the following eight subcortical structures: lateral ventricles, thalamus, caudate, putamen, pallidum, hippocampus, amygdala and nucleus accumbens. Two hundred and twenty-six control subjects, ranging in age from 19 to 85. years, were scanned on a 1.5. T GE system (n= 184) or a 3.0. T Siemens system (n= 42). Volumes of subcortical structures, adjusted for cranium size, were estimated using FSL's FIRST software, which is fully automated. Significant age effects were found for all volumes when the entire age range was analyzed; however, the older subjects (60-85. years of age) showed a stronger correlation between age and structural volume for the ventricles, hippocampus, amygdala and accumbens than middle-aged (35-60. years of age) subjects. Middle-aged subjects were studied at both sites, and age effects in these groups were comparable, despite differences in magnet strength and acquisition systems. This agreement lends support to the validity of the image-analysis tools and procedures used in the present study.
机译：使用磁共振成像技术在以下八个皮层下结构中调查了正常对照志愿者的横断面年龄影响：侧脑室，丘脑，尾状，壳状核，苍白质，海马，杏仁核和伏隔核。在1.5上对22例年龄在19至85岁之间的对照受试者进行了扫描。 T GE系统（n = 184）或3.0。 T西门子系统（n = 42）。使用FSL的FIRST软件（完全自动化）估算了根据颅骨大小调整的皮层下结构的体积。当分析整个年龄范围时，发现所有年龄段的显着年龄影响;然而，年龄较大的受试者（60-85。岁）与中年（35-60。岁）的受试者相比，脑室，海马，杏仁核和伏隔的年龄与结构体积之间的相关性更强。在两个地点都对中年受试者进行了研究，尽管磁铁强度和采集系统存在差异，但这些组的年龄影响是可比的。该协议为本研究中使用的图像分析工具和程序的有效性提供了支持。

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