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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Depression and anxiety in adults with sickle cell disease: the PiSCES project.
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Depression and anxiety in adults with sickle cell disease: the PiSCES project.

机译：成人镰状细胞疾病患者的抑郁和焦虑：PiSCES项目。

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OBJECTIVE: Depression and anxiety are common in sickle cell disease (SCD) but relatively little is known about their impact on SCD adults. This study measured prevalence of depression and anxiety in SCD adults, and their effects on crisis and noncrisis pain, quality-of-life, opioid usage, and healthcare utilization. METHODS: The Pain in Sickle Cell Epidemiology Study is a prospective cohort study in 308 SCD adults. Baseline variables included demographics, genotype, laboratory data, health-related quality-of-life, depression, and anxiety. Subjects completed daily diaries for up to 6 months, reporting sickle cell pain intensity, distress, interference, whether they were in a sickle cell crisis, as well as health care and opioid utilization. RESULTS: Two hundred thirty-two subjects who completed at least 1 month of diaries were studied; 27.6% were depressed and 6.5% had any anxiety disorder. Depressed subjects had pain on significantly more days than nondepressed subjects (mean pain days 71.1% versus 49.6%, p < .001). When in pain on noncrisis days, depressed subjects had higher mean pain, distress from pain, and interference from pain. Both depressed and anxious subjects had poorer functioning on all eight SF-36 subscales, even after controlling for demographics, hemoglobin type, and pain. The anxious subjects had more pain, distress from pain, and interference from pain, both on noncrisis pain days and on crisis days, and used opioids more often. CONCLUSIONS: Depression and anxiety predicted more daily pain and poorer physical and mental quality-of-life in adults with SCD, and accounted for more of the variance in all domains of quality-of-life than hemoglobin type.
机译：目的：抑郁症和焦虑症在镰状细胞病（SCD）中很常见，但对其对SCD成人的影响知之甚少。这项研究测量了SCD成人抑郁症和焦虑症的患病率，以及它们对危机和非危机疼痛，生活质量，阿片类药物使用和医疗保健利用的影响。方法：镰状细胞流行病学疼痛研究是一项针对308名SCD成人的前瞻性队列研究。基线变量包括人口统计学，基因型，实验室数据，与健康有关的生活质量，抑郁和焦虑。受试者每天完成长达6个月的日记，报告镰状细胞疼痛强度，困扰，干扰，是否处于镰状细胞危机以及医疗保健和阿片类药物的利用。结果：研究了232名完成了至少1个月日记的受试者。抑郁者占27.6％，焦虑症占6.5％。抑郁的受试者比非抑郁的受试者痛苦多得多（平均疼痛日为71.1％对49.6％，p <.001）。在非危机日出现疼痛时，沮丧的受试者会出现较高的平均疼痛，因疼痛而苦恼以及因疼痛而受到干扰。即使在控制了人口统计学，血红蛋白类型和疼痛之后，抑郁和焦虑的受试者在所有八个SF-36分量表上的功能均较差。无论是在非危机性疼痛日还是在危机日，焦虑症患者都有更多的痛苦，痛苦困扰和痛苦干扰，并且更频繁地使用阿片类药物。结论：抑郁和焦虑预示着患有SCD的成年人每天的疼痛会越来越多，身心生活质量也较差，并且在所有生活质量领域的变异都比血红蛋白类型多。

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