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首页> 外文期刊>Urology >Intravesical potassium sensitivity in patients with interstitial cystitis and urethral syndrome.
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Intravesical potassium sensitivity in patients with interstitial cystitis and urethral syndrome.

机译：间质性膀胱炎和尿道综合征患者的膀胱内钾敏感性。

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OBJECTIVES: To examine populations with diagnosed clinical interstitial cystitis (IC) and urethral syndrome and normal controls using the potassium sensitivity test (PST), to determine the incidence of PST-provoked pain and/or urgency, and to document the type and location of IC and urethral syndrome pain, association of pain with sexual intercourse, and family history of female urgency/frequency problems. METHODS: The PST and a questionnaire were administered to 466 patients with clinical IC, 116 patients with urethral syndrome, and 42 controls. RESULTS: The PST was positive in 78% of patients with clinical IC, in 55% of patients with urethral syndrome, and in 0% of the controls. Of the patients with clinical IC, 9% responded to the PST with pain only and 8% with urgency only. Patients with clinical IC reported the pain as dysuria (58%), urethral/vaginal (76%), above the pubic bone (53%), lower abdomen (47%), lower back (35%), vaginal (51%), and inguinal (28%). The results were similar for patients with urethral syndrome. Of the sexually active men and women, 71% with clinical IC and 59% with urethral syndrome reported pain associated with intercourse. Urgency/frequency problems in female relatives were reported by 35% of patients with IC and 33% of those with urethral syndrome. CONCLUSIONS: The significant potassium sensitivity in both patients with clinical IC and those with urethral syndrome and the absence of potassium sensitivity in normal controls indicates that a positive PST suggests the presence of an abnormal bladder epithelium. The lower rate of positive PSTs in patients with urethral syndrome reflects the less severe, more intermittent, nature of the symptoms in urethral syndrome (early IC). Pelvic pain of bladder origin may occur anywhere in the pelvis. Finally, IC appears to have a genetic component.
机译：目的：使用钾敏感性试验（PST）检查诊断为临床间质性膀胱炎（IC）和尿道综合征以及正常对照的人群，以确定PST引起的疼痛和/或紧迫性的发生率，并记录其类型和位置IC和尿道综合征疼痛，疼痛与性交的关联以及女性尿急/频率问题的家族史。方法：对466例临床IC患者，116例尿道综合征患者和42例对照者进行PST和问卷调查。结果：78％的临床IC患者，55％的尿道综合征患者和0％的对照者PST阳性。在具有临床IC的患者中，只有9％的患者对PST有反应，而只有紧急情况的患者才有8％。具有临床IC的患者报告的疼痛为排尿困难（58％），尿道/阴道（76％），耻骨以上（53％），小腹（47％），下背部（35％），阴道（51％）和腹股沟（28％）。尿道综合征患者的结果相似。在性活跃的男性和女性中，有71％患有临床IC，而59％患有尿道综合症的患者报告与性交相关的疼痛。 35％的IC患者和33％的尿道综合症患者报告了女性亲属的紧急/频率问题。结论：临床IC患者和尿道综合症患者对钾的敏感性均很高，而正常对照者对钾的敏感性均不高，这表明PST阳性表明存在膀胱上皮异常。尿道综合症患者的PST阳性率较低，反映出尿道综合症症状的严重程度较低，间歇性更强（早期IC）。膀胱起源的骨盆疼痛可能发生在骨盆的任何地方。最后，IC似乎具有遗传成分。

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