• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chemistry: A European journal >Electron-transfer reactions through the associated interaction between cytochrome c and self-assembled monolayers of optically active Cobalt(III) complexes: Molecular recognition ability induced by the chirality of the Cobalt(III) units
【24h】

Electron-transfer reactions through the associated interaction between cytochrome c and self-assembled monolayers of optically active Cobalt(III) complexes: Molecular recognition ability induced by the chirality of the Cobalt(III) units

机译：通过细胞色素c和光学活性钴（III）配合物的自组装单层之间的关联相互作用进行电子转移反应：由钴（III）单元的手性诱导的分子识别能力

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Self-assembled monolayers (SAMs) of optically active Co-III complexes ((S)-2/(R)-2) that contain (S)- or (R)-phenylalanine derivatives as a molecular recognition site were constructed on Au electrodes ((S)-2-Au/(R)-2Au). Molecular recognition characteristics induced by the S and R configurations were investigated by measurements of electron-transfer reactions with horse heart cytochrome c (cyt c). The electrochemical studies indicate that the maximum current of cyt c reduction is obtained when the Au electrode is modified by 2 with a moderate coverage of approximately 4.0 x 10(-11) mol cm(-2). Since the Au electrode is not densely packed with the Co-III units at this concentration, we conclude that the penetrative association process between cyt c and the Co-III unit plays an important role in this electron-transfer system. The differences in the electron-transfer rates of (S)-2-Au and (R)-2-Au increase with increasing scan rates, a result indicating that the chiral ligand has an influence on the rate of association of the complexes with cyt c. 3-Au has a mixed monolayer composed of 2 and hexanethiol and exhibits electron-transfer behavior comparable to 2-Au. The difference in the association rates of (S)-3-Au and (R)-3-Au is larger than that between (S)-2-Au and (R)-2-Au, which indicates that the molecular recognition ability of 3-Au has been enhanced by filling the gap between molecules of 2 with hexanethiols. The differences in the oxidation rates of cyt c(II) between (S)-2-Au and (R)-2-Au and between (S)-3-Au and (R)-3-Au were larger than the differences in the rates of the reduction of cyt c(III); this suggests that the size of the heme crevice varies according to the oxidation state of cyt c.
机译：在Au电极上构建了包含（S）-或（R）-苯丙氨酸衍生物作为分子识别位点的光学活性Co-III配合物（（S）-2 /（R）-2）的自组装单层（SAMs） （（S）-2-Au /（R）-2Au）。通过测量与马心脏细胞色素c（cyt c）进行的电子转移反应，研究了由S和R构型诱导的分子识别特性。电化学研究表明，当Au电极被2修饰时，具有约4.0 x 10（-11）mol cm（-2）的适度覆盖率，可获得cyt c还原的最大电流。由于在该浓度下Au电极没有被Co-III单元紧密地堆积，因此我们得出结论，cyt c和Co-III单元之间的渗透缔合过程在该电子转移系统中起着重要的作用。 （S）-2-Au和（R）-2-Au电子传递速率的差异随扫描速率的增加而增加，结果表明手性配体对复合物与胞嘧啶的缔合速率有影响。 C。 3-Au具有由2和己硫醇组成的混合单层，并具有与2-Au相当的电子转移性能。 （S）-3-Au和（R）-3-Au的缔合速率差异大于（S）-2-Au和（R）-2-Au的缔合速率差异，这表明分子识别能力通过用己硫醇填充2分子之间的间隙，提高了3-Au的原子能级。 （S）-2-Au和（R）-2-Au之间以及（S）-3-Au和（R）-3-Au之间cyt c（II）氧化速率的差异大于差异cyt c（III）的减少率;这表明血红素缝隙的大小根据cyt c的氧化状态而变化。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号