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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Longitudinal Association of Dementia and Depression
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Longitudinal Association of Dementia and Depression

机译：老年痴呆症和抑郁症纵向协会

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Objectives: Depression is an important precursor to dementia, but less is known about the role dementia plays in altering the course of depression. We examined whether depression prevalence, incidence, and severity are higher in those with dementia versus those with mild cognitive impairment (MCI), or normal cognition. Design: Prospective cohort study using the longitudinal Uniform Data Set of the National Alzheimer's Coordinating Center (2005-2013). Setting: 34 Alzheimer Disease research centers. Participants: 27,776 subjects with dementia, MCI, or normal cognition. Measurements: Depression status was determined by a clinical diagnosis of depression within the prior 2 years and by a Geriatric Depression Scale-Short Form score > 5. Results: Rates of depression were significantly higher in subjects with MCI and dementia compared with those with normal cognition at index visit. Controlling for demographics and common chronic conditions, logistic regression analysis revealed elevated depression in those with MCI (OR: 2.40 [95% CI: 2.25, 2.56]) or dementia (OR: 2.64 [95% CI: 2.43, 2.86]) relative to those with normal cognition. In the subjects without depression at the index visit (N = 18,842), those with MCI and dementia had higher probabilities of depression diagnosis 2 years post index visit than those with normal cognition: MCI - 21.7%, dementia - 24.7%, normal cognition - 10.5%. Conclusion: MCI and dementia were associated with significantly higher rates of depression in concurrent as well as prospective analyses. These findings suggest that efforts to effectively engage and treat older adults with dementia will need also to address co-occurring depression.
机译：目的：抑郁症是痴呆症的重要先兆，但对于痴呆症在改变抑郁症过程中所起的作用知之甚少。我们检查了痴呆症患者的抑郁症患病率，发病率和严重程度是否高于轻度认知障碍（MCI）或正常认知者。设计：使用国家阿尔茨海默氏症协调中心的纵向统一数据集进行前瞻性队列研究（2005-2013年）。地点：34个老年痴呆症研究中心。参与者：27,776名患有痴呆症，MCI或正常认知的受试者。测量：抑郁状态由前两年内的抑郁症临床诊断以及老年抑郁量表-简式得分> 5来确定。结果：MCI和痴呆症患者的抑郁症发病率明显高于正常认知者在索引访问中。控制人口统计学和常见慢性病，逻辑回归分析显示，相对于MCI（OR：2.40 [95％CI：2.25，2.56]）或痴呆症（OR：2.64 [95％CI：2.43，2.86]）的抑郁症患者升高那些具有正常认知能力的人。在没有就诊时出现抑郁的受试者（N = 18,842）中，有MCI和痴呆症的患者在就诊后2年的抑郁诊断几率高于具有正常认知能力的受试者：MCI-21.7％，痴呆-24.7％，正常认知- 10.5％。结论：MCI和痴呆与同时进行的前瞻性分析与抑郁症的发生率显着相关。这些发现表明，有效参与和治疗老年痴呆症的努力还需要解决共同发生的抑郁症。

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