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首页> 外文期刊>The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry >Comparative electrochemical study of new self-assembled monolayers of 2-{[(Z)-1-(3-furyl)methylidene]amino}-1-benzenethiol and 2-{[(2-sulfanylphenyl) imino]methyl}phenol for determination of dopamine in the presence of high concentration of ascorbic acid and uric acid
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Comparative electrochemical study of new self-assembled monolayers of 2-{[(Z)-1-(3-furyl)methylidene]amino}-1-benzenethiol and 2-{[(2-sulfanylphenyl) imino]methyl}phenol for determination of dopamine in the presence of high concentration of ascorbic acid and uric acid

机译：测定2-{[（（Z）-1-（3-呋喃基）亚甲基]氨基} -1-苯硫醇和2-{[（（2-硫烷基苯基）亚氨基]甲基}苯酚的新自组装单分子层的比较电化学研究高浓度抗坏血酸和尿酸存在下的多巴胺

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The comparative electrochemical behavior of self-assembled monolayers of two Schiff's bases, 2-{[(Z)-1-(3-furyl)methylidene]amino}-1-benzenethiol (FMAB) and 2-{[(2-sulfanylphenyl)imino]methyl}phenol (SIMP) on a bare gold electrode (Au FMAB SAM-modified electrode and Au SIMP SAM-modified electrode, respectively), was investigated by means of cyclic voltammetry and electrochemical impedance spectroscopy in a 0.1 mol L~(-1) KCl solution that contains 5.0 × 10~(-3) mol L~(-1) [Fe(CN) _6]~(3-/4-). The results revealed that the modified electrodes showed an electrocatalytic activity toward the anodic oxidation of dopamine by a marked enhancement in the current response and lower overpotential (60 and 90 mV for the Au FMAB and Au SIMP SAM-modified electrodes, respectively) in phosphate buffer solution at pH 6.0. The Au SIMP SAM-modified electrode was applied successfully to the determination of dopamine in the presence of a high concentration of ascorbic acid. Selective detection was realized in total elimination of ascorbic acid response - a method different from the ones based on the potential separations. The detection limit of dopamine was 5.0 × 10~(-8) mol L~(-1) in a linear range from 1.0 × 10 ~(-6) to 1.2 × 10~(-4) mol L~(-1) in the presence of 1.0 × 10~(-3) mol L~(-1) ascorbic acid. The interference studies also showed that the Au SIMP SAM-modified electrode exhibited good selectivity in the presence of a large excess of uric acid and could be employed for the determination of dopamine in pharmaceutical formulations, plasma samples and human urine with adequate selectivity and precision.
机译：两种席夫氏碱自组装单层的比较电化学行为，即2-{[（（Z）-1-（3-呋喃基）亚甲基]氨基} -1-苯硫醇（FMAB）和2-{[（（2-硫烷基苯基）通过循环伏安法和电化学阻抗谱法在0.1 mol L〜（-）的条件下研究了裸金电极（分别为Au FMAB SAM修饰电极和Au SIMP SAM修饰电极）上的亚氨基]甲基}苯酚（SIMP）。 1）KCl溶液，其中含有5.0×10〜（-3）mol L〜（-1）[Fe（CN）_6]〜（3- / 4-）。结果表明，修饰的电极在磷酸盐缓冲液中表现出电流响应的显着增强和较低的过电势（Au FMAB和Au SIMP SAM修饰电极分别为60和90 mV），从而显示出对多巴胺阳极氧化的电催化活性。 pH 6.0的溶液。 Au SIMP SAM修饰的电极在高浓度抗坏血酸存在下成功地用于测定多巴胺。选择性检测是在完全消除抗坏血酸反应中实现的，这种方法不同于基于电位分离的方法。多巴胺的检出限在1.0×10〜（-6）到1.2×10〜（-4）mol L〜（-1）的线性范围内为5.0×10〜（-8）mol L〜（-1）。在1.0×10〜（-3）mol L〜（-1）抗坏血酸的存在下。干扰研究还表明，Au SIMP SAM修饰的电极在存在大量过量的尿酸的情况下显示出良好的选择性，并且可以以足够的选择性和精密度用于测定药物制剂，血浆样品和人尿中的多巴胺。

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