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Effective obesity treatments

机译：有效的肥胖治疗

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To curb the epidemic of obesity in the United States, revised Medicare policy allows support for efficacious obesity treatments. This review summarizes the evidence from rigorous randomized trials (9 lifestyle trials, 5 drug trials, and 2 surgical trials) on the efficacy and risk-benefit profile of lifestyle, drug, and surgical interventions aimed at promoting sustained (>= 2 years) reductions in weight. Both lifestyle and drug interventions consistently produced an approximate 7-lb (3.2-kg) weight loss that was sustained for 2 years and was associated with improvements in diabetes, blood pressure, and/or cardiovascular risk factors. Surgical interventions have a less solid empirical base but offer promise for the promotion of significant and sustained weight reduction posttreatment in the morbidly obese but with possible significant short-term side effects. In summary, there is strong and consistent support from rigorous randomized trials that lifestyle or drug interventions result in modest weight loss with minimal risks but disproportionate clinical benefit. Combinations of lifestyle, drug, and, where appropriate, surgical interventions may be the most efficacious approach to achieving sustained weight loss for the widest diversity of patients.
机译：为了遏制肥胖症在美国的流行，修订后的Medicare政策允许对有效的肥胖症治疗提供支持。这篇综述总结了严格的随机试验（9项生活方式试验，5项药物试验和2项外科手术试验）的证据，这些证据涉及旨在促进持续（> = 2年）减少的生活方式，药物和外科手术干预的功效和风险效益概况重量。生活方式干预和药物干预均持续产生约7磅（3.2千克）的体重减轻，持续2年，并与糖尿病，血压和/或心血管危险因素的改善相关。外科手术的经验基础较差，但有望为病态肥胖的患者在治疗后促进显着且持续的减轻体重提供可能，但可能具有短期显着的副作用。总而言之，严格的随机试验提供了强有力的一致支持，即生活方式或药物干预可减轻体重，风险最小，但临床获益却不成比例。生活方式，药物和适当的外科手术干预相结合可能是最有效的方法，以实现对最广泛患者的持续减肥。

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