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Authors' reply

机译：作者的回信

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Authors' reply: We agree with Downs & Jonas that it is important to establish whether the association between inter-pregnancy interval and schizophrenia is indeed causal, and that residual confounding is a potential explanation for our findings. Residual confounding is, of course, a potential explanation for any association in observational epidemiological studies, as we discuss in our paper. However, we believe that one of the strengths of our study is that we compare the relationship between the pre-birth inter-pregnancy interval and risk of schizophrenia with that of the post-birth inter-pregnancy interval and risk of this disorder. If the association between pre-birth inter-pregnancy interval and risk of schizophrenia is due to confounding, we would expect to observe a similar relationship for the post-birth interval, but we did not find this in our study. Although it is possible that there are confounders that are associated with pre-birth, but not post-birth inter-pregnancy intervals, this seems rather unlikely for most potential confounders.
机译：作者的回答：我们同意Downs＆Jonas的观点，即确定怀孕间隔与精神分裂症之间的关联是否确实是因果关系非常重要，并且残留的混杂因素可能是我们发现的潜在原因。正如我们在本文中所讨论的，残留混杂无疑是观察流行病学研究中任何关联的潜在解释。但是，我们认为，本研究的优势之一是，我们比较了出生前的怀孕间隔与精神分裂症风险与出生后的怀孕间隔与精神分裂症风险之间的关系。如果出生前的怀孕间隔与精神分裂症风险之间的关联是由于混杂引起的，那么我们期望在出生后的间隔中观察到类似的关系，但是我们在研究中并未发现这一点。尽管可能存在与出生前相关的混杂因素，但与妊娠后间隔无关，但是对于大多数潜在的混杂因素而言，这似乎不太可能。

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