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首页> 外文期刊>The British journal of psychiatry : >Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study
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Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study

机译：健康老年痴呆症患者的焦虑症状，脑淀粉样蛋白负荷和记忆力下降：3年前瞻性队列研究

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Although beta-amyloid, anxiety and depression have been linked cross-sectionally to reduced memory function in healthy older adults without dementia, prospective data evaluating these associations are lacking. Using data from an observational cohort study of 178 healthy older adults without dementia followed for 3 years, we found that anxiety symptoms significantly moderated the relationship between beta-amyloid level and decline in verbal (Cohen's d = 0.65) and episodic (Cohen's d = 0.38) memory. Anxiety symptoms were additionally linked to greater decline in executive function, irrespective of beta-amyloid and other risk factors. These findings suggest that interventions to mitigate anxiety symptoms may help delay memory decline in otherwise healthy older adults with elevated beta-amyloid.
机译：尽管β淀粉样蛋白，焦虑症和抑郁症与健康的没有痴呆症的老年人的横断面相关联，但缺乏评估这些关联的前瞻性数据。使用一项对178名无痴呆的健康老年人进行了为期3年的观察性队列研究的数据，我们发现焦虑症状显着缓解了β淀粉样蛋白水平与言语下降（Cohen d = 0.65）和发作性下降（Cohen d = 0.38）之间的关系。 ）的内存。焦虑症状还与执行功能的更大下降相关，而与β-淀粉样蛋白和其他危险因素无关。这些发现表明，缓解焦虑症状的干预措施可能有助于延迟健康的β-淀粉样蛋白升高的成年人的记忆衰退。

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