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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Diagnostic criteria of dementia.
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Diagnostic criteria of dementia.

机译：痴呆症的诊断标准。

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In the past two decades there has been a tremendous effort among clinicians and searchers to improve the diagnostic criteria of the dementias on the basis of the differential neurological and neuropsychological profiles. This was an obligatory requirement for clinical trials and the development of treatments. Over the years it became rapidly evident that the cohorts of patients in studies had some degree of heterogeneity, making it difficult to interpret the results of some studies, particularly in the vascular dementias and the mild cognitive impairment (MCI) group. For example, many sub-types of the vascular group were included in clinical trials, such as the cortical strokes, the lacunar states and the diffuse white matter disease cases, and some of the patients might have had also mixed pathology. In addition, the standard DSM IV criteria for dementia no longer represent our present knowledge of the clinical profile of some of the dementias such as vascular dementia (VaD) and fronto-temporal dementia where the memory impairment is not necessarily the first requirement. To improve the validity of clinical trials and eventually help developing more appropriate treatments, we revised the present diagnostic criteria and made recommendations for some changes in the context of the 2nd Canadian Conference on the Development of Antidementia Therapies, held in 2004 and reviewed in the light of the recent literature as of early 2006. It is expected that in the near future, these dementia criteria for clinical trials will have to be revised again in order to include specific subtypes of the dementias as well as biomarkers, structural and functional imaging.
机译：在过去的二十年中，临床医生和研究人员为基于痴呆症的神经和神经心理学特征改善痴呆症的诊断标准做出了巨大的努力。这是临床试验和治疗方法的强制性要求。多年以来，越来越明显的是，研究中的患者群体具有一定程度的异质性，使得难以解释某些研究的结果，尤其是在血管性痴呆和轻度认知障碍（MCI）组中。例如，临床试验中包括了许多血管亚型，例如皮质中风，腔隙性疾病和弥漫性白质病病例，而且某些患者可能还患有混合病理。此外，痴呆症的标准DSM IV标准不再代表我们目前对某些痴呆症的临床概况的了解，例如血管性痴呆（VaD）和额颞痴呆，其中记忆障碍不一定是首要要求。为了提高临床试验的有效性并最终帮助开发更合适的治疗方法，我们修订了当前的诊断标准，并针对2004年举行的第二届加拿大抗痴呆疗法发展会议（以下简称“会议”）提出了一些建议。这些信息来自2006年初的最新文献。预计在不久的将来，必须重新修订这些痴呆症临床试验标准，以包括痴呆症的特定亚型以及生物标志物，结构和功能成像。

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