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Non-motor symptoms and parkinsonism

机译:非运动症状和帕金森综合症

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摘要

Since the original description in 1817 by James Parkinson, the disease that bears his name has been recognized to be a disorder of the dopaminergic system affecting the substantia nigra pars compacta. Diagnosis of Parkinson disease (PD) has been based on the classical motor symptoms of bradykinesia, rigidity, and rest tremor, and treatment concentrated on dopamine replacement strategies. Using the currently available therapies, most patients experience many years of good motor function, as well as decreased mortality.
机译:自1817年詹姆士·帕金森(James Parkinson)最初进行描述以来,以他的名字命名的疾病已被认为是影响黑质致密部的多巴胺能系统疾病。帕金森病(PD)的诊断基于运动迟缓,僵硬和静息性震颤的典型运动症状,治疗重点在于多巴胺替代策略。使用当前可用的疗法,大多数患者经历了多年良好的运动功能,并降低了死亡率。

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