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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >In Process Citation
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In Process Citation

机译：过程中引用

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OBJECTIVE: The prevalence of depression in Parkinson's disease (PD) raises the issues of the difficulties of diagnosing the condition and of the relationships between depression and the natural history of the disease. METHODS: A cohort of 135 consecutive patients with idiopathic PD underwent psychiatric (DSM-III-R, Goldberg depression scale), neurological (distinguishing "axial" signs from other signs of parkinsonism), and neuropsychological (particularly frontal tests) evaluations. RESULTS: Depression is present in more than half of the patients and it seems to be more frequent in patients with the akinetic and fluctuating forms of the disease. The subjects who are depressed do not have a greater degree of cognitive impairment, but their scores on frontal tests are higher. Moreover, the axial signs of the disease (postural instability, axial rigidity) are more severe in depressed parkinsonians suggesting a link between depression and the non-dopaminergic lesions of the disease. Even though slowness, appetite and sleep disturbances, and fatigue may be encountered in non-depressed parkinsonian patients, separation of the parkinsonian population into subgroups shows that certain symptoms are never seen in parkinsonians who are not depressed: it is thus evident that the impression that life is not worth living impression of being worthless and incompetent", "the low level of energy", the morning sadness Parkinsonian depression has two major clinical forms. The first one is associated with a greater number of somatic manifestations: sleep disturbances, morning fatigue. corresponding to more severe depression with hopelessness and loss of self confidence. The second exhibits few somatic manifestations with apathy and slowness as frequent complaints. CONCLUSIONS: This study defines the symptoms of parkinsonian depression which should be better recognised in order to be treated. The link between depression and axial signs of the disease may explain why L-dopa and dopaminergic agonists improve the motor signs of depression without influencing depressive manifestations in most cases.
机译：目的：帕金森病（PD）的抑郁症患病率使人们难以诊断病情以及抑郁症与疾病自然史之间的关系。方法：对一组连续的135例特发性PD患者进行了精神病学（DSM-III-R，戈德堡抑郁量表），神经学（与其他帕金森病症状相区别的“轴向”体征）和神经心理学（特别是额叶试验）评估。结果：抑郁症在一半以上的患者中出现，并且在该疾病的运动性和波动性患者中似乎更常见。抑郁的受试者没有更大程度的认知障碍，但是他们在额叶测验中的得分更高。此外，在抑郁的帕金森病中，该疾病的轴向体征（姿势不稳，轴向僵硬）更为严重，这表明抑郁症与该疾病的非多巴胺能性病变之间存在联系。即使在非抑郁的帕金森氏症患者中可能会遇到缓慢，食欲和睡眠障碍以及疲劳，但将帕金森氏症人群分为亚组表明，在没有抑郁的帕金森氏症患者中从未见到某些症状：因此，很明显，生活不值得过活，“一文不值和无能的印象”，“精力低下”，晨起帕金森氏抑郁症有两种主要的临床表现形式：第一种与更多的躯体表现有关：睡眠障碍，早晨疲劳结论：帕金森氏抑郁症的症状应得到更好的认识，以便进行治疗。抑郁症与疾病轴向征兆之间的联系可能解释了为什么左旋多巴和多巴胺在大多数情况下，胺能激动剂可改善抑郁症的运动症状，而不会影响抑郁表现。

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