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首页> 外文期刊>The International journal of drug policy >'You've got m@il: Fluoxetine coming soon!': Accessibility and quality of a prescription drug sold on the web
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'You've got m@il: Fluoxetine coming soon!': Accessibility and quality of a prescription drug sold on the web

机译：“您已经有了m @ il：氟西汀即将上市！”：网络上出售的处方药的可及性和质量

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Background: The increasing phenomenon of online pharmacies has potential for serious public health problems. This study aimed to evaluate the possibility of accessing a prescription drug in the absence of a prescription for an Italian purchaser. Methods: Fluoxetine pills were ordered from several online pharmacies. The study included website analysis, and the quality of the received product including packaging, chemical and microbiological analyses. Results: Orders could be placed correctly on 61 of the 98 selected websites, and a sales transaction was concluded successfully on 17 websites. Thirteen drug samples were eventually received. In one case it was necessary to fill in a questionnaire before ordering the drugs. All websites displayed aggressive marketing strategies. There was wide variation in terms of domain registration, company base (when declared) and manufacturer's location (mostly India). All pills were delivered in sealed blister packs showing the lot number and manufacturer's details. A leaflet was enclosed in one case only. In three cases we received more pills than ordered, and in one case Viagra pills as a free gift. Pharmacopoeia microbiological requirements were satisfied. Chemical analysis revealed that the active principle was always present, although many samples did not meet the Pharmacopoeia "other impurities" or "total impurities" criteria. Heavy metals and solvents regulated by the Pharmacopoeia did not exceed the set limits; some of the non-regulated ones were also assessed, in some cases with a positive result (e.g. styrene). Conclusion: About 20% of purchase attempts resulted in delivery of the drugs, even in the absence of a medical prescription. Traceability was poor and drug quality was generally worse compared to conventional pharmacy-purchased products. Based on all these broad-spectrum results, user safety appears not to be globally guaranteed.
机译：背景：网上药房现象的增多有可能导致严重的公共卫生问题。这项研究旨在评估在没有意大利购买者处方的情况下获得处方药的可能性。方法：氟西汀药片是从多家在线药房订购的。该研究包括网站分析，以及所收到产品的质量，包括包装，化学和微生物分析。结果：可以在98个选定网站中的61个上正确下订单，并且在17个网站上成功完成了销售交易。最终收到了十三份药物样品。在一种情况下，有必要在订购药物之前填写调查表。所有网站都展示了激进的营销策略。域名注册，公司基础（声明时）和制造商所在地（主要是印度）之间存在很大差异。所有药丸均装在密封的泡罩包装中，以显示批号和制造商的详细信息。仅在一种情况下随附传单。在三种情况下，我们收到的药丸数量超过订购的数量，在一种情况下，伟哥药丸是免费赠送的。满足药典微生物学要求。化学分析表明，尽管许多样品不符合药典中的“其他杂质”或“总杂质”标准，但活性成分始终存在。药典规定的重金属和溶剂未超过设定的限值;还评估了一些不受管制的产品，在某些情况下（例如苯乙烯）得到了肯定的结果。结论：即使没有医疗处方，约有20％的购买尝试导致药物的交付。与传统的药房购买产品相比，可追溯性差，药品质量通常较差。基于所有这些广谱的结果，似乎不能保证全球范围内的用户安全。

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