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首页> 外文期刊>Protoplasma: An International Journal of Cell Biology >Migration of epidermal keratinocytes: mechanisms, regulation, and biological significance
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Migration of epidermal keratinocytes: mechanisms, regulation, and biological significance

机译：表皮角质形成细胞的迁移：机制，调控和生物学意义。

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摘要

Keratinocytes are the prevalent cell type of the epidermis, a multilayered cornified epithelium which provides the cellular basis of the outermost barrier between the organism and its environment. By this barrier function the epidermis protects the organism against a variety of environmental hazards such as dehydration and mechanical stress. Under normal conditions, keratinocytes of all layers are interconnected by desmosomes and anchored by hemidesmosomes to a specialised type of extracellular matrix. the basement membrane. When the epidermis is injured. a vitally important response is initiated with the aim to restore the protective function of the epithelium. A fast but provisional sealing is achieved by the deposition of the fibrin clot before within 24 It after wounding keratinocytes from the wound margins begin to migrate into the wound bed, where they start to proliferate and to form the new epithelium. The development of new high-resolution assays for the study of cell migration and motility has potentiated major progress in our understanding, of keratinocyte migration in vitro and in situ. The data reviewed here point to a sophisticated cooperation between soluble motogenic growth factors. cell-matrix interactions, and cell-to-cell communications as major parts of the machinery regulating keratinocyte migration.
机译：角质形成细胞是表皮的普遍细胞类型，是一种多层的角质化上皮，它为生物与其环境之间的最外层屏障提供了细胞基础。通过这种屏障功能，表皮可以保护生物体免受各种环境危害，例如脱水和机械应力。在正常条件下，所有层的角质形成细胞通过桥粒相互连接，并通过半桥粒锚定在特定类型的细胞外基质上。基底膜。当表皮受伤时。为了恢复上皮的保护功能，开始了至关重要的反应。快速而临时的封闭是通过在24内之内之前沉积血纤蛋白凝块来实现的。在伤口周围的角质形成细胞从伤口边缘开始受伤后开始迁移到伤口床中，在那里它们开始增殖并形成新的上皮细胞。用于研究细胞迁移和运动性的新的高分辨率检测方法的发展，已经增强了我们对角质形成细胞体外和原位迁移的了解的重大进展。此处审查的数据指出了可溶性运动发生生长因子之间的复杂合作。细胞-基质相互作用和细胞间通讯是调节角质形成细胞迁移的主要手段。

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