Does 2,3-butanedione monoxime inhibit nonmuscle myosin?

Forer A; Fabian L

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Does 2,3-butanedione monoxime inhibit nonmuscle myosin?

机译：2,3-丁二酮单肟抑制非肌肉肌球蛋白吗？

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BDM (2,3-butanedione monoxime) has been used extensively to inhibit nonmuscle myosin. However, recent articles raise the question of what BDM actually does, because of experiments in which BDM did not affect the actin-activated ATPase of nonmuscle myosins. We describe results that indicate that BDM indeed inhibits motility due to nonmuscle myosins: in many different cells BDM has the same effects as anti-actin agents and/or as other anti-myosin agents, and BDM slows or stops the sliding between actin filaments and myosin in vitro. We discuss how the two sets of apparently contradictory results might be resolved, and we suggest possible experiments that might clarify the contradictory interpretations.

机译：BDM（2,3-丁二酮一肟）已被广泛用于抑制非肌肉肌球蛋白。但是，最近的文章提出了BDM实际作用的问题，因为实验中BDM不会影响肌非球蛋白的肌动蛋白激活的ATPase。我们描述的结果表明，BDM确实由于非肌肉肌球蛋白而抑制了运动：在许多不同的细胞中，BDM与抗肌动蛋白药物和/或其他抗肌球蛋白药物具有相同的作用，而BDM可以减缓或阻止肌动蛋白丝与肌动蛋白丝之间的滑动。体外肌球蛋白。我们讨论了如何解决两组明显矛盾的结果，并提出了可能阐明矛盾解释的可能的实验。

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《Protoplasma: An International Journal of Cell Biology》 |2005年第2期|共4页
作者
Forer A; Fabian L;
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正文语种 eng
中图分类细胞形态学;
关键词
2; 3-butanedione monoxime; myosin; motility; actin-activated ATPase; CRANE-FLY SPERMATOCYTES; ACTIN CYTOSKELETON; SKELETAL-MUSCLE; HAIR-CELLS; F-ACTIN; MICROTUBULES; ACTOMYOSIN; TRANSPORT; MOVEMENT; TURNOVER;

机译：2;3-丁二酮一肟;肌球蛋白;运动性;肌动蛋白激活的ATPase;CRANE蝇精子细胞;肌动蛋白细胞骨架;骨骼肌;毛发细胞;F-肌动蛋白;微管;肌动蛋白;运输;运动;营业额;

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专利

1. Does 2,3-butanedione monoxime inhibit nonmuscle myosin? [J] . Arthur Forer, Lacramioara Fabian Protoplasma . 2005,第1a2期

机译：2,3-丁二酮单肟抑制非肌肉肌球蛋白吗？
2. Myocyte contractility can be maintained by storing cells with the myosin ATPase inhibitor 2,3 butanedione monoxime [J] . Charles Mechas Physiological Reports . 2015,第6期

机译：肌球蛋白ATPase抑制剂2,3丁二酮一肟可以储存细胞，从而维持心肌的收缩力
3. The myosin ATPase inhibitor, 2,3-butanedione 2-monoxime, prevents protein secretion by the basidiomycete Coprinopsis cinerea [J] . Hashimoto Kohsuke, Yokota Etsuo, Shimmen Teruo, Biotechnology Letters . 2011,第4期

机译：肌球蛋白ATPase抑制剂2,3-丁二酮2-一肟，可以防止灰担子菌（Coprinopsis cinerea）的分泌
4. Effect of 2,3 Butanedione Monoxime (BDM) on ventricular fibrillation [C] . Malik, M., Gopalakrishnan, . 2002

机译：2,3丁二酮单肟（BDM）对心室纤颤的影响
5. Studies on Functions of Nonmuscle Myosin II Isoforms in Actin--Microtubule Crosstalk [D] . 佐藤, 勇太 2019

机译：非肌肌球蛋白II同工型在肌动蛋白-微管串扰中的功能研究
6. Myocyte contractility can be maintained by storing cells with the myosin ATPase inhibitor 23 butanedione monoxime [O] . Charles S Chung, Charles Mechas, Kenneth S Campbell 2015

机译：肌球蛋白ATPase抑制剂23丁二酮一肟可以储存细胞从而维持心肌的收缩力
7. Myocyte contractility can be maintained by storing cells with the myosin ATPase inhibitor 2,3 butanedione monoxime [O] . Charles S. Chung, Charles Mechas, Kenneth S. Campbell 2015

机译：可以通过用肌球蛋白ATP酶抑制剂2,3丁酰胺单肟（Monoxime）来维持肌细胞收缩力
8. Reactive Skin Decontaminant Reactivity Studies: The Effect of O-Acetyl 2,3-Butanedione Monooxime on the Stability of 2,3-butanedione Monooximate [R] . Clewley, R. G., Purdon, J. G., Chenier, C. L. 1992

机译：反应性皮肤去污反应性研究：O-乙酰基2,3-丁二酮单肟对2,3-丁二酮单氧化物稳定性的影响

Does 2,3-butanedione monoxime inhibit nonmuscle myosin?

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