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Problems with currently available antidepressants.

机译:当前可用的抗抑郁药存在问题。

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摘要

Although options for pharmacologic treatment for depression have grown seemingly exponentially over the past several decades, the current armamentarium of antidepressants continues to have limitations of both efficacy and tolerability. The problems include an unacceptable lack of efficacy, delayed onset of therapeutic effects, an inability to predict responses to one or another agent, drug-drug interactions, and difficulty with tolerability during both acute and chronic treatment. This article reviews the problems that persist in the use of currently available antidepressant medications and presents a list of attributes that would be characteristic of the ideal antidepressant.
机译:尽管在过去的几十年中,抑郁症的药物治疗选择似乎呈指数增长,但当前的抗抑郁药装备仍然在功效和耐受性方面都受到限制。这些问题包括无法接受的疗效不足,治疗效果的延迟发作,无法预测对一种或另一种药物的反应,药物与药物的相互作用以及急性和慢性治疗期间的耐受性困难。本文回顾了使用当前可用的抗抑郁药仍然存在的问题,并提出了理想抗抑郁药的特征清单。

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