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Use of quetiapine in elderly patients.

机译:老年患者使用喹硫平。

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摘要

Behavioral problems associated with psychosis in the elderly have a significant negative impact on patients' quality of life and can lead to placement in a nursing home. Because of their decreased propensity to produce extrapyramidal symptoms, atypical antipsychotics such as quetiapine hold promise in the treatment of these vulnerable patients. Quetiapine may, in theory, be particularly advantageous in this regard because of its lack of anticholinergic activity and its relatively loose binding to dopamine receptors. This article reviews the somewhat limited number of clinical studies of the use of quetiapine in treating older patients with schizophrenia and other psychotic disorders, patients with psychosis associated with Alzheimer's disease or dementia with Lewy bodies, and patients with Parkinson's disease and drug-induced psychosis.
机译:与老年人精神病相关的行为问题会对患者的生活质量产生重大的负面影响,并可能导致其进入疗养院。由于它们产生锥体束外症状的倾向降低,非典型抗精神病药物如喹硫平有望用于治疗这些脆弱患者。从理论上讲,喹硫平在这方面可能是特别有利的,因为它缺乏抗胆碱能活性,并且与多巴胺受体的结合相对较松散。本文回顾了使用喹硫平治疗老年精神分裂症和其他精神病患者,患有阿尔茨海默氏病或​​路易体痴呆的精神病患者以及帕金森氏病和药物诱发的精神病患者的临床研究数量有限。

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