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首页> 外文期刊>The journal of clinical psychiatry >Neuropathologic changes in Alzheimer's disease.
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Neuropathologic changes in Alzheimer's disease.

机译：阿尔茨海默氏病的神经病理变化。

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Alzheimer's disease is characterized by degenerative changes in a variety of neurotransmitter systems. These include alterations in the function of the monoaminergic neural systems that release glutamate, norepinephrine, and serotonin as well as a few neuropeptide-containing systems. Alzheimer's disease is also characterized by degenerative changes in selected brain regions, including the temporal and parietal lobes and restricted regions within the frontal cortex and cingulate gyrus. The degeneration of these systems may underlie specific aspects of the dementia associated with Alzheimer's disease. A major problem in Alzheimer's disease research today is that none of the current hypothesized mechanisms are able to explain the cellular and regional distribution pattern that characterizes the neuropathology of Alzheimer's disease. This article summarizes the nature and extent of the changes associated with neural systems, possible treatment approaches, and a potential mechanism involving chronic neuroinflammation to explain the pattern of neuropathologic changes in Alzheimer's disease.
机译：阿尔茨海默氏病的特征是多种神经递质系统的变性变化。这些包括释放谷氨酸，去甲肾上腺素和5-羟色胺的单胺能神经系统的功能改变，以及一些含神经肽的系统。阿尔茨海默氏病的特征还在于所选大脑区域的退行性变化，包括颞叶和顶叶以及额叶皮层和扣带回内的限制性区域。这些系统的退化可能是与阿尔茨海默氏病相关的痴呆症特定方面的基础。当今阿尔茨海默氏病研究的一个主要问题是，当前的任何假设机制都无法解释表征阿尔茨海默氏病神经病理学的细胞和区域分布模式。本文总结了与神经系统相关的变化的性质和程度，可能的治疗方法以及涉及慢性神经发炎的潜在机制，以解释阿尔茨海默氏病的神经病理学变化模式。

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