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首页> 外文期刊>The journal of clinical psychiatry >Sleep and depression.
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Sleep and depression.

机译：睡眠和抑郁。

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BACKGROUND: Of all the psychiatric disorders associated with insomnia, depression is the most common. It has been estimated that 90% of patients with depression complain about sleep quality. Since the first reports of short rapid eye movement (REM) latency in depressed patients and of the effect of sleep deprivation on depression in the 1970s, numerous sleep studies have provided extensive observations and theoretical hypotheses concerning the etiology and pathophysiology of depression. The aim of this review is to summarize knowledge regarding the relationships between sleep and depression. DATA SOURCES AND SELECTION: MEDLINE and PsycINFO searches of the literature published in English or French between 1964 and 2005 that examined the relationships between sleep disturbance and depression were conducted. Search terms used were depression, depressive disorder, affective disorder, mood disorders, seasonal affective disorder, sleep, sleep disorders, insomnia, REM, polysomnography, sleep deprivation, electroencephalography, PET, SPECT, and fMRI. DATA SYNTHESIS: Two hundred five papers were identified and selected and then integrated into the following categories: sleep architecture, antidepressive therapies, age- and gender-associated differences, functional imaging results, and sleep-related hypotheses explaining the pathophysiology of depression. CONCLUSION: Numerous studies provide findings indicating the remarkable relationship between sleep alterations and depression. Although the existing hypotheses are not likely to explain all aspects of the sleep alterations in depression, each may be worth being maintained for refinements of pathophysiologic models of depression as new data accumulate. Further research taking into account the heterogeneity of depressive disorder and linking the different areas of research is needed to develop more comprehensive theoretical models and new therapies for depression.
机译：背景：在与失眠有关的所有精神疾病中，抑郁是最常见的。据估计，有90％的抑郁症患者抱怨睡眠质量。自从1970年代首次报道抑郁症患者的快速眼球运动（REM）潜伏期短和睡眠不足对抑郁症的影响以来，许多睡眠研究就抑郁症的病因和病理生理学提供了广泛的观察结果和理论假设。这篇综述的目的是总结关于睡眠与抑郁之间关系的知识。数据来源和选择：MEDLINE和PsycINFO对1964年至2005年之间以英文或法文出版的文献进行了检索，这些文献检查了睡眠障碍与抑郁之间的关系。使用的搜索词是抑郁症，抑郁症，情感障碍，情绪障碍，季节性情感障碍，睡眠，睡眠障碍，失眠，REM，多导睡眠图，睡眠剥夺，脑电图，PET，SPECT和fMRI。数据综合：鉴定并选择了255篇论文，然后将其整合到以下类别中：睡眠结构，抗抑郁疗法，与年龄和性别相关的差异，功能成像结果以及与睡眠相关的假说，它们解释了抑郁症的病理生理学。结论：大量研究提供了表明睡眠改变和抑郁之间显着关系的发现。尽管现有的假设不可能解释抑郁症中睡眠改变的所有方面，但随着新数据的积累，可能值得维护每个方面，以完善抑郁症的病理生理模型。需要进一步研究，考虑到抑郁症的异质性，并将研究的不同领域联系起来，以开发更全面的理论模型和抑郁症的新疗法。

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