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Issues in treatment-resistant depression.

机译:难治性抑郁症的问题。

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Major depressive disorder is a debilitating disease that imposes significant social and economic burdens not only on patients but also on society. Although various treatment options are available, treatment-resistant depression is common. Determining the exact prevalence of treatment-resistant depression is difficult because definitions vary, as do definitions of antidepressant response. Operational definitions of antidepressant response, nonresponse, partial response, and remission will be discussed in this article. Pharmacotherapy options for patients with treatment-resistant depression include augmentation, combination, and switching therapies; however, data from controlled clinical trials supporting these therapies are limited. Electroconvulsive therapy and psychotherapy offer additional treatment strategies. New nonpharmacologic therapies are under investigation. Remission is the goal of treatment.
机译:严重的抑郁症是一种使人衰弱的疾病,不仅对患者而且对社会都造成巨大的社会和经济负担。尽管有多种治疗方法可供选择,但耐治疗性抑郁症很常见。确定抗药性抑郁症的确切患病率很困难,因为定义和抗抑郁药反应的定义不同。本文将讨论抗抑郁药反应,无反应,部分反应和缓解的操作定义。难治性抑郁症患者的药物治疗选择包括增强,联合和转换疗法;但是,来自支持这些疗法的受控临床试验的数据有限。电惊厥疗法和心理疗法提供了其他治疗策略。新的非药物疗法正在研究中。缓解是治疗的目标。

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