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首页> 外文期刊>The journal of clinical psychiatry >Schizophrenia-associated idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome).
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Schizophrenia-associated idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome).

机译：精神分裂症相关的特发性未结合的高胆红素血症（吉尔伯特综合征）。

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BACKGROUND: Idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome) is a benign hyperbilirubinemia found in the general population. There has been only 1 previous report of Gilbert's syndrome occurring in schizophrenic patients. The present study was conducted to determine the frequency of Gilbert's syndrome in schizophrenic patients relative to patients with other psychiatric disorders. METHOD: Plasma bilirubin concentrations of every patient admitted to the psychiatric hospital during a 3-year period were collected, and patients were examined to exclude all other causes of hyperbilirubinemia. In addition, the psychiatric symptoms of schizophrenic patients (ICD-10 criteria) with hyperbilirubinemia were evaluated by the Positive and Negative Syndrome Scale (PANSS). RESULTS: Schizophrenic patients showed a significantly higher incidence of hyperbilirubinemia (p < .05) relative to patients suffering from other psychiatric disorders, and schizophrenic patients with hyperbilirubinemia showed significantly higher scores on the positive and general psychiatric subscales of the PANSS (p < .0001) than patients without hyperbilirubinemia. CONCLUSION: The apparently higher frequency of Gilbert's syndrome in schizophrenic patients may reflect a relationship between hyperbilirubinemia and schizophrenic psychosis. Hypothetical explanations, such as a possible genetic disposition for Gilbert's syndrome, an increased vulnerability of red cell membranes, and the role of estrogens in schizophrenic patients, are discussed.
机译：背景：特发性非结合性高胆红素血症（吉尔伯特综合征）是在普通人群中发现的良性高胆红素血症。以前只有1篇报道精神分裂症患者发生吉尔伯特综合症。进行本研究是为了确定精神分裂症患者相对于其他精神疾病患者的吉尔伯特综合征的发生频率。方法：收集每位3年入精神病医院的患者的血浆胆红素浓度，并对患者进行检查以排除所有其他原因引起的高胆红素血症。此外，通过阳性和阴性综合征量表（PANSS）评估患有高胆红素血症的精神分裂症患者的精神病症状（ICD-10标准）。结果：精神分裂症患者高胆红素血症的发生率显着高于其他精神疾病患者（p <.05），精神分裂症高胆红素血症患者在PANSS的阳性和一般精神量表上得分均明显更高（p <.0001 ）比没有高胆红素血症的患者高。结论：精神分裂症患者吉尔伯特综合征的频率明显升高，可能反映了高胆红素血症和精神分裂症精神病之间的关系。讨论了一些假设性的解释，例如吉尔伯特综合症的可能遗传特征，红细胞膜的易感性增加以及雌激素在精神分裂症患者中的作用。

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