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Brain volume in depression

机译:抑郁症的脑容量

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摘要

To the Editor: In their excellent article in the May 2012 issue of the Journal,1 Phillips et al demonstrated brain-volume increase in patients with treatment-resistant unipolar depression in sustained remission. Similar to previous studies in this area, no mention was made regarding the nature of brain volume decrease in depression. Is the brain volume increase in remitted patients in this study the function of regeneration of atrophied neurons or of increase in the number of glial cells, or both, in the affected area of the brain? Also, no mention was made concerning the status of Cortisol hypersecretion in nonremirting depressed patients. It would be helpful to learn whether a correlation exists between positive dexamethasone suppression test status and brain atrophy in nonremitted depression.
机译:致编者:Phillips等人在2012年5月《期刊》上的出色文章中1,证明了在持续缓解中具有治疗抵抗力的单相抑郁症患者的脑容量增加。与该领域以前的研究类似,没有提及抑郁症中脑容量减少的性质。在这项研究中,缓解的患者的大脑容量增加是萎缩神经元的再生功能,还是在患病区域的神经胶质细胞数量增加,或两者都有?此外,也没有提及关于在未复习的抑郁症患者中皮质醇过度分泌的状况。了解地塞米松抑制试验阳性状态与非缓解型抑郁症的脑萎缩之间是否存在相关性将是有帮助的。

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