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Dietary restrictions and drug interactions with monoamine oxidase inhibitors: An update

机译:饮食限制和与单胺氧化酶抑制剂的药物相互作用:最新进展

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摘要

Monoamine oxidase inhibitors (MAOIs) are effective treatments for depression that has atypical features or that has failed to respond to other antidepressants. However, MAOIs are underused because clinicians are concerned about dietary and drug interactions with this class of medication. Hypertensive crisis and serotonin syndrome can occur in rare cases due to interactions between MAOIs and foods containing tyramine as well as interactions with serotonergic and sympathomimetic agents. A better understanding of the foods and drugs that can cause adverse reactions, as well as knowledge of newer MAOIs with mechanisms of action and delivery methods that reduce these risks, may help clinicians to consider the use of these medications, when appropriate, in their patients with depression.
机译:单胺氧化酶抑制剂(MAOI)是具有非典型特征或对其他抗抑郁药无反应的抑郁症的有效治疗方法。但是,由于临床医生担心与此类药物的饮食和药物相互作用,因此未充分使用MAOI。在少数情况下,由于MAOI与含酪胺的食物之间的相互作用以及与血清素能和拟交感神经药的相互作用,可能会发生高血压危机和血清素综合征。更好地了解可能引起不良反应的食物和药物,以及对具有降低这些风险的作用机制和给药方法的新型MAOI的了解,可能有助于临床医生在适当情况下考虑在患者中使用这些药物沮丧。

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