Quantifying Intraindividual Variations in Plasma Clozapine Levels: A Population Pharmacokinetic Approach

Lee Jimmy; Bies Robert; Takeuchi Hiroyoshi; Fervaha Gagan; Bhaloo Amaal; Powell Valerie; Remington Gary

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Quantifying Intraindividual Variations in Plasma Clozapine Levels: A Population Pharmacokinetic Approach

机译：量化血浆clozapine水平的intraindividual个人差异：人口药代动力学方法。

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Objective: Clozapine has strong recommendations for therapeutic drug monitoring. While factors that influence interindividual variation in plasma clozapine levels have been extensively reported, intraindividual variation remains poorly studied. We employed a population pharmacokinetic approach to assess intraindividual variations in plasma levels of both clozapine and N-desmethylclozapine, as well as the impact of smoking on this variability.

机译：目的：氯氮平对治疗药物监测有强烈建议。尽管已经广泛报道了影响血浆氯氮平水平个体间差异的因素，但对个体间差异的研究仍很少。我们采用了群体药代动力学方法来评估氯氮平和N-去甲基氯氮平的血浆水平的个体差异以及吸烟对这种变异性的影响。

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来源
《The journal of clinical psychiatry》 |2016年第5期|共7页
作者
Lee Jimmy; Bies Robert; Takeuchi Hiroyoshi; Fervaha Gagan; Bhaloo Amaal; Powell Valerie; Remington Gary;
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正文语种 eng
中图分类精神病学;
关键词
Antidepressants; Psychopharmacology; Schizophrenia;

机译：抗抑郁药;心理药理学;精神分裂症;

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专利

1. Quantifying Intraindividual Variations in Plasma Clozapine Levels: A Population Pharmacokinetic Approach [J] . Amaal Bhaloo, Gagan Fervaha, Gary Remington, Primary care companion to the journal of clinical psychiatry . 2016,第5期

机译：定量血浆氯氮平水平的intraindividual变化：人口药代动力学方法。
2. Evidence from a population pharmacokinetics analysis for a major effect of CYP1A2 activity on inter- and intraindividual variations of clozapine clearance. [J] . Dailly E, Urien S, Chanut E, Progress in Neuro-Psychopharmacology & Biological Psychiatry: An International Research, Review and News Journal . 2002,第4期

机译：CYP1A2活性对氯氮平清除率的个体间和个体间变异的主要影响的群体药代动力学分析的证据。
3. Intraindividual variation of microRNA expression levels in plasma and peripheral blood mononuclear cells and the associations of these levels with the pathogenesis of autoimmune thyroid diseases [J] . Otsu Hiroshi, Watanabe Mikio, Inoue Naoya, Clinical chemistry and laboratory medicine: CCLM . 2017,第5期

机译：血浆和外周血单个核细胞中微小荷纳表达水平的细分变异以及这些水平与自身免疫性甲状腺疾病发病机制的关联
4. High Resolution Accurate Mass MS and MS/MS for Simultaneous Quantitative and Qualitative Analysis in Complex Biological Samples: Pharmacokinetics Analysis and Metabolite Identification of Clozapine [C] . Na Pi, Shane E. Tichy, Adam Amaral, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：高分辨率精确的质量MS和MS / MS，用于复杂生物样品中同时定量和定性分析：药代动力学分析和氯氮平的代谢物鉴定
5. Beta-lactam antimicrobial dosing optimization in obese patients compared to non-obese patients using population pharmacokinetic/pharmacodynamic approach. [D] . Chung, Eun Kyoung. 2015

机译：使用群体药代动力学/药效学方法，与非肥胖患者相比，肥胖患者的β-内酰胺抗菌药物剂量优化。
6. Identifying 24 h variation in the pharmacokinetics of levofloxacin: a population pharmacokinetic approach [O] . Laura Kervezee, Jasper Stevens, Willem Birkhoff, 2016

机译：确定左氧氟沙星药代动力学的24小时变化：群体药代动力学方法
7. Confounding factors for variation of clozapine plasma levels: drug interactions with proton pump inhibitor or infectious etiologies? [O] . Wagner, Sophie, Varet-Legros, M. G., Fabre, Claudine, 2010

机译：氯氮平血浆水平变化的混杂因素：药物与质子泵抑制剂的相互作用或传染病因？

Quantifying Intraindividual Variations in Plasma Clozapine Levels: A Population Pharmacokinetic Approach

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