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首页> 外文期刊>The Journal of dermatology >Psoriasis and metabolic syndrome
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Psoriasis and metabolic syndrome

机译:牛皮癣和代谢综合征

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Psoriasis is a chronic inflammatory and immune-mediated disease associated with several comorbidities, such as obesity, hypertension, diabetes mellitus, dyslipidemia and cardiovascular disorder. These comorbidities are components of metabolic syndrome. The pathogenesis of metabolic syndrome is supposed to be related to increased levels of adipocytokines, such as tumor necrosis factor-α (TNF-α) and adiponectin. Recent study has revealed a high prevalence of metabolic syndrome in psoriatics compared with other skin diseases. Biologic agents, including anti-TNF-α antibodies, are recommended as the first-line treatment for psoriatics with metabolic syndrome. This article reviews the association of psoriasis and metabolic syndrome in terms of adipocytokines and evaluates the role of biologic agents in the treatment of psoriasis.
机译:银屑病是一种慢性炎症和免疫介导的疾病,与多种合并症有关,例如肥胖,高血压,糖尿病,血脂异常和心血管疾病。这些合并症是代谢综合征的组成部分。代谢综合征的发病机制被认为与脂肪细胞因子水平升高有关,例如肿瘤坏死因子-α(TNF-α)和脂联素。最近的研究表明,与其他皮肤病相比,银屑病的代谢综合征患病率较高。推荐将包括抗TNF-α抗体在内的生物制剂作为代谢综合征银屑病的一线治疗药物。本文从脂肪细胞因子的角度回顾了银屑病与代谢综合征的关系,并评估了生物制剂在银屑病治疗中的作用。

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