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首页> 外文期刊>The Journal of dermatology >Superficial CD34-positive fibroblastic tumor: A new case from Japan
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Superficial CD34-positive fibroblastic tumor: A new case from Japan

机译：浅表CD34阳性的成纤维细胞肿瘤：日本新病例

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摘要

A 48-year-old Japanese woman presented with a painless, slow-growing, brown nodule of 15 mm in diameter on the left thigh. She noticed the nodule a few years before the first presentation to our hospital. She underwent total resection of the nodule. On histopathological examination, a relatively well-defined tumor with infiltrative growth was located in the dermis and extended into the subcutis. The tumor was composed of spindle to polygonal cells with pleomorphic nuclei arranged in a sheet-like or fascicular pattern. Tumor cells with granular cytoplasm were also scattered. Immunohistochemical examination revealed that the tumor cells were strongly positive for CD34. The fusion transcripts of the collagen type 1 alpha 1 platelet-derived growth factor beta chain were not detected. After excluding other fibroblastic tumors through histopathological and immunohistochemical examinations, a diagnosis of superficial CD34-positive fibroblastic tumor (SCPFT) was made. SCPFT is a recently proposed fibroblastic tumor that is characterized by striking pleomorphism, granular cytoplasm, low mitotic rate and diffuse CD34 expression. Only two reports with 20 cases have been reported so far. The present case is the first that corresponds to SCPFT in Japan.
机译：一名48岁的日本女性在左大腿上出现了直径15毫米的无痛，缓慢生长的棕色结节。在第一次到我院就诊前几年，她注意到了这个结节。她对结节进行了完全切除。在组织病理学检查中，具有浸润性生长的相对明确的肿瘤位于真皮内并延伸至皮下组织。肿瘤由纺锤形到多边形细胞组成，多形核呈片状或束状排列。具有粒状细胞质的肿瘤细胞也被分散。免疫组织化学检查显示，肿瘤细胞对CD34呈强阳性。未检测到胶原1型1血小板衍生的生长因子β链的融合转录本。通过组织病理学和免疫组化检查排除其他成纤维细胞瘤后，对CD34阳性的成纤维细胞表面肿瘤（SCPFT）进行了诊断。 SCPFT是最近提出的一种成纤维细胞性肿瘤，其特征是惊人的多态性，颗粒状细胞质，低有丝分裂率和CD34弥散表达。迄今为止，仅报告了两起涉及20例病例的报告。本案是日本第一个与SCPFT相对应的案件。

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