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首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >High On-Treatment Platelet Reactivity Associated With Prasugrel
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High On-Treatment Platelet Reactivity Associated With Prasugrel

机译：普拉格雷与治疗相关的高血小板反应性

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Objective: To report a case of high on-treatment platelet reactivity (HTPR) with prasugrel maintenance therapy despite adequate initial platelet response to a loading dose. Case Summary: A 51-year-old woman presented to the emergency department complaining of chest pain. She was diagnosed with acute-on-chronic systolic heart failure and non-ST-elevated myocardial infarction (Ml). She had a previous Ml with bare metal stent placement and was taking aspirin and prasugrel 10 mg daily. Once admitted, a P2Y_12 assay revealed HTPR (331 PRU); therefore, prasugrel was reloaded (60 mg). The next day a P2Y_12 assay showed adequate platelet reactivity inhibition (118 PRU), so prasugrel 10 mg daily was continued in the hospital and on discharge. Seventeen days after discharge she was readmitted for possible ischemia. On day 3 of admission, a P2Y_12 assay revealed HTPR (278 PRU); subsequently, prasugrel was discontinued and ticagrelor started. After 3 doses of ticagrelor, a P2Y_12 assay was 97 PRU, so ticagrelor was continued. Five months have passed since discharge. The patient continues to take ticagrelor and has had no further cardiac events. Discussion: HTPR indicates hypo- or
机译：目的：报告一例普拉格雷维持疗法治疗后血小板反应性高（HTPR）的病例，尽管初始血小板对负荷剂量有足够的反应。病例摘要：一名51岁的妇女因出现胸痛而被送往急诊科。她被诊断出患有急性慢性收缩性心力衰竭和非ST升高的心肌梗塞（M1）。她之前曾接受过裸金属支架植入的Ml，并且每天服用阿司匹林和普拉格雷10 mg。入院后，P2Y_12分析显示HTPR（331 PRU）;因此，普拉格雷重新装填（60毫克）。第二天，P2Y_12检测显示出足够的血小板反应性抑制（118 PRU），因此在医院和出院时继续每天10 mg普拉格雷。出院后十七天，她因可能的局部缺血再次入院。入院第3天，P2Y_12检测显示HTPR（278 PRU）;随后，停止使用普拉格雷，并开始替卡格雷治疗。给予替卡格雷的3剂后，P2Y_12测定值为97 PRU，因此继续替卡格雷。自放电以来已经过去了五个月。患者继续服用替格瑞洛，并且没有进一步的心脏事件。讨论：HTPR指示低或

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