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首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >Medication Repurposing: New Uses for Old Drugs
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Medication Repurposing: New Uses for Old Drugs

机译：重用药物：旧药的新用途

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Background: Medication repurposing, the practice of using old drugs in new ways, is becoming more common. Old drugs that had previously fallen out of favor due to safety concerns, lack of efficacy, or development of more desirable therapeutic alternatives have been resurfacing in the literature and on pharmacy shelves. Developing new uses for old drugs may provide patients with access to helpful therapies but may also present challenges and risks.Objective: To explore the rationale for, and historical context of, the developing trend of recycling existing drugs for new, innovative uses, and to provide pharmacy practitioners with information about how to find clinical evidence regarding these new uses.Data Synthesis: The process of obtaining marketing approval for new drugs can take an average of over 10 years and exceed Dollars 1 billion. Repurposing old drugs (both approved and unapproved) for new uses requires considerably fewer resources since information about production needs, pharmacology, and pharmacokinetics is already known. Other advantages of using old drugs include faster availability for patient use and known safety concerns for the original indication. Disadvantages of new uses for old drugs may include lack of clinical evidence, unknown safety for the new clinical context, limited availability of information about new uses, and liability or legal concerns. Several methods of identifying potential new uses exist, including the observance of previously unknown desirable pharmacologic effects during clinical use, new knowledge of a mechanism of action leading to exploration of innovative therapeutic areas, or screening compound libraries for targeted clinical activity.Conclusions: There are many examples of recycling existing medications for new purposes. Pharmacy practitioners should be aware of this developing trend and know how to find information about utilizing old drugs in new ways.
机译：背景：以药物治疗为目的，以新方式使用旧药物的做法正变得越来越普遍。以前由于安全性问题，缺乏疗效或开发出更理想的治疗替代品而失宠的旧药物已在文献和药房中重新出现。开发旧药物的新用途可能为患者提供有用的疗法，但也可能带来挑战和风险。目的：探讨回收现有药物用于新的创新用途的发展趋势的理由和历史背景，以及数据综合：获得新药上市许可的过程平均需要10年以上，超过10亿美元。数据综合：向药剂师提供有关如何查找这些新用途的临床证据的信息。由于已知有关生产需求，药理学和药代动力学的信息，将旧药（批准的和未批准的）重新用于新用途需要的资源要少得多。使用旧药物的其他优点包括可以更快地为患者使用以及原始适应症的已知安全性问题。旧药物新用途的劣势可能包括缺乏临床证据，对新临床环境的安全性未知，关于新用途的信息可用性有限以及责任或法律问题。存在几种识别潜在新用途的方法，包括在临床使用过程中观察先前未知的理想药理作用，对导致探索创新治疗领域的作用机制的新知识，或针对目标临床活性筛选化合物库。回收现有药物用于新用途的许多示例。药房从业者应意识到这种发展趋势，并知道如何找到有关以新方式利用旧药的信息。

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