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首页> 外文期刊>The Journal of Veterinary Medical Science >Therapeutic Changes of Plasma N-Terminal Pro-Brain Natriuretic Peptide Concentrations in 9 Dogs with Patent Ductus Arteriosus
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Therapeutic Changes of Plasma N-Terminal Pro-Brain Natriuretic Peptide Concentrations in 9 Dogs with Patent Ductus Arteriosus

机译：9例动脉导管未闭犬的血浆N末端脑前利钠肽浓度的治疗性变化

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The plasma N-terminal proBNP (NT-proBNP) concentration is measured for determining the diagnosis and severity of heart failure in dogs. However, ills still unclear whether measurements of circulating NT-proBNP levels provide clinical utility as an indicator of therapeutic efficacy. Thus, we investigated the surgical correction-related changes of plasma NT-proBNP concentrations in 9 dogs with patent ductus arteriosus (PDA). Physical examination, thoracic radiography and echocardiography were conducted both before and after surgery. Similarly, the plasma NT-proBNP concentrations were determined using an enzyme immunoassay for canine pro-BNP. The International Small Animal Cardiac Health Council (ISACHC) class and murmur grade were significantly improved after surgery compared with before surgery. Vertebral heart size (VHS) and cardiothoracic ratio (CTR) were significantly decreased after surgery. Fractional shortening was significantly decreased and relative wall thickness (RWT) was significantly increased after surgery. Furthermore, the plasma NT-proBNP concentrations were significantly decreased by surgical correction. The plasma NT-proBNP concentration showed significant positive correlation with the ISACHC class, murmur grade, VHS and CTR and significant negative correlation with the RWT. Therefore, measurement of plasma NT-proBNP levels can be used to monitor the effectiveness of therapies such as surgical correction of PDA.
机译：测量血浆N末端proBNP（NT-proBNP）浓度，以确定狗的心衰诊断和严重程度。然而，仍然不清楚循环NT-proBNP水平的测量是否可作为治疗功效的指标提供临床实用性。因此，我们调查了9例动脉导管未闭（PDA）犬血浆NT-proBNP浓度与手术校正相关的变化。手术前后均进行体格检查，胸片和超声心动图检查。类似地，使用针对犬前BNP的酶免疫测定法测定血浆NT-proBNP浓度。与手术前相比，手术后国际小动物心脏健康委员会（ISACHC）等级和杂音等级明显改善。手术后椎体心脏大小（VHS）和心胸比率（CTR）明显降低。手术后，分数缩短明显减少，相对壁厚（RWT）显着增加。此外，通过手术矫正显着降低了血浆NT-proBNP浓度。血浆NT-proBNP浓度与ISACHC分类，杂音等级，VHS和CTR呈显着正相关，与RWT呈显着负相关。因此，血浆NT-proBNP水平的测量可用于监测治疗的有效性，例如PDA的手术矫正。

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