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首页> 外文期刊>The journal of sexual medicine >Tadalafil Enhances the Inhibitory Effects of Tamsulosin on Neurogenic Contractions of Human Prostate and Bladder Neck
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Tadalafil Enhances the Inhibitory Effects of Tamsulosin on Neurogenic Contractions of Human Prostate and Bladder Neck

机译：他达拉非增强坦洛新对人前列腺和膀胱颈部神经源性收缩的抑制作用。

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Introduction. Lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH-LUTSs) may be associated with erectile dysfunction (ED). Phosphodiesterase type 5 (PDE5) inhibitors used for treating ED have shown clinical benefit in patients with LUTS but their actions in human LUT tissues are not well defined. Aim. To determine the effects of the long-acting PDE5 inhibitor, tadalafil, on smooth muscle tone in human prostate and bladder neck as well as to evaluate the influence of tadalafil on the efficacy of the α-adrenergic receptor antagonist, tamsulosin, in inhibiting contractile responses in these tissues. Methods. Strips of human peripheral prostate (HPP), human internal prostate (HIP), and human bladder neck (HBN) were obtained from organ donors and patients with BPH. The strips were then disposed in organ baths to evaluate nitric oxide/cyclic guanosine monophosphate (cGMP)-mediated relaxation and cGMP kinetics in HPP and HIP, and electrical field stimulation (EFS)-induced neurogenic contractions in HPP and HBN. Main Outcome Measures. Tadalafil-induced effects on sodium nitroprusside (SNP)-induced relaxation and cGMP accumulation in HPP and HIP and influence of tadalafil and tamsulosin on EFS-induced contractions of HPP and HBN. Results. SNP-induced relaxation of HPP and HIP was significantly potentiated by tadalafil (30-60nM). SNP-induced cGMP accumulation in HPP and HIP was enhanced by tadalafil (30-60nM), but significant difference was only obtained in HPP. EFS-induced contractions sensitive to tetrodotoxin in HPP were significantly inhibited by tadalafil (30nM) but not by tamsulosin (0.01-100nM) or vehicle. Further inhibition of neurogenic responses in HPP was achieved by combining tadalafil and tamsulosin treatments. Tamsulosin, but not tadalafil, significantly reduced EFS-induced contractions in HBN, but the coadministration of both therapies resulted in additional inhibition of contractions. Conclusions. While tadalafil enhances cGMP accumulation and potentiates prostate relaxation, tadalafil combined with tamsulosin results in enhanced inhibition of neurogenic contractions of HPP and HBN.
机译：介绍。继发于良性前列腺增生（BPH-LUTS）的下尿路症状可能与勃起功能障碍（ED）有关。用于治疗ED的5型磷酸二酯酶（PDE5）抑制剂已在LUTS患者中显示出临床益处，但它们在人LUT组织中的作用尚不明确。目标。为了确定长效PDE5抑制剂他达拉非对人前列腺和膀胱颈平滑肌张力的影响，并评估他达拉非对α-肾上腺素能受体拮抗剂坦索罗辛抑制收缩反应的功效的影响在这些组织中。方法。从器官供体和BPH患者获得人外周前列腺（HPP），人内部前列腺（HIP）和人膀胱颈（HBN）的条带。然后将试纸条置于器官浴中，以评估一氧化氮/环鸟苷一磷酸（cGMP）介导的HPP和HIP中的松弛和cGMP动力学，以及电场刺激（EFS）引起的HPP和HBN中的神经源性收缩。主要观察指标。他达拉非对硝普钠（SNP）诱导的HPP和HIP松弛和cGMP积累的影响以及他达拉非和坦洛新对EFS诱导的HPP和HBN收缩的影响。结果。他达拉非（30-60nM）可显着增强SNP诱导的HPP和HIP松弛。他达拉非（30-60nM）增强了SNP诱导的HPP和HIP中cGMP的积累，但仅HPP获得了显着差异。他达拉非（30nM）显着抑制EFS诱导的HPP对河豚毒素敏感的收缩，但坦洛新（0.01-100nM）或赋形剂则无明显抑制作用。通过联合他达拉非和坦索罗辛治疗，进一步抑制HPP中的神经源性反应。坦索罗辛（而非他达拉非）可显着减少EFS诱导的HBN收缩，但两种疗法的共同给药可进一步抑制收缩。结论。他达拉非可增强cGMP积累并增强前列腺松弛，但他达拉非与坦洛新联合使用可增强对HPP和HBN神经源性收缩的抑制作用。

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