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Death by testosterone? We think not!

机译:睾丸激素导致死亡?我们认为不是!

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摘要

A recently published article in JAMA alleging increased risk of death, myocardial infarction (MI), and stroke in men who received testosterone (T) therapy has generated considerable concern regarding the safety of T therapy among the global medical community, as well as among the lay public [1]. This follows a highly publicized report published in the New England Journal of Medicine in 2010 in which a T trial in elderly frail men was terminated prematurely because of increased cardiovascular events in men who received T compared with men who received placebo [2]. Given the rapid increase in the use of T therapy over the last decade, it is critical to gain an appreciation of the risks of this treatment, particularly cardiovascular risks and mortality. We here provide our analysis of these concerning publications, as well as a broader perspective on the relationship of T to cardiovascular disease.
机译:最近在JAMA上发表的一篇文章称接受睾丸激素(T)治疗的男性死亡,心肌梗塞(MI)和中风的风险增加,这已引起全球医学界以及全球医学界对T治疗安全性的广泛关注。公开[1]。在此之前,2010年在《新英格兰医学杂志》上发表了一篇广为宣传的报告,该报告中,由于接受T疗法的男性患者与接受安慰剂的男性相比,心血管事件增加,因此提前终止了对年老体弱的男性的T试验[2]。鉴于最近十年来T疗法的使用量迅速增加,因此,重要的是要了解这种疗法的风险,尤其是心血管疾病的风险和死亡率。我们在这里提供对这些相关出版物的分析,以及T与心血管疾病之间关系的更广阔视野。

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