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首页> 外文期刊>The New England journal of medicine >Therapeutic hypothermia after cardiac arrest.
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Therapeutic hypothermia after cardiac arrest.

机译：心脏骤停后的治疗性体温过低。

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to the editor: Data showing that therapeutic hypothermia benefits patients after cardiac arrest originate from two clinical trials. One small trial involving 77 patients used quasi-randomiza-tion and an unusual outcome measure. The larger trial2 included only 275 of 3551 potential participants, had no predefined power calculation, and was terminated early. Neither trial maintained normothermia in the control group. Accordingly, these trials cannot reliably prove benefit or harm in the majority of patients who currently receive this form of treatment, and consequently the efficacy of hypothermia is not universally accepted. Holzer's comprehensive review mentions additional areas of uncertainty, including the use of milder hypothermia, application in asystole, and effects on the predictive value of evoked potentials and biomarkers of brain injury. Target Temperature Management After Cardiac Arrest (CIinicalTrials.gov number, NCT01020916) is an international trial designed to compare the effect of a temperature target of 36 deg C versus 33 deg C in 850 patients resuscitated from out-of-hospital cardiac arrest. The trial population will be broader and larger than those in previous trials and consequently more representative of patients who are currently being treated with hypothermia.
机译：致编辑：数据显示，低温治疗使心脏骤停后的患者受益，来自两项临床试验。一项涉及77位患者的小型试验使用了准随机化和一种不寻常的结局指标。较大的试验2仅包括3551个潜在参与者中的275个，没有预先定义的功效计算，并且提前终止。两项试验均未在对照组中维持常温。因此，这些试验不能可靠地证明目前正在接受这种治疗方式的大多数患者的获益或危害，因此低温疗法的疗效尚未被普遍接受。 Holzer的全面审查提到了其他不确定性领域，包括使用温和的低温治疗，在心搏停止中的应用以及对诱发电位和脑损伤生物标志物的预测价值的影响。心脏骤停后的目标温度管理（CIinicalTrials.gov号，NCT01020916）是一项国际试验，旨在比较850例因院外心脏骤停而复苏的患者的36℃和33℃温度目标的效果。该试验人群将比以前的试验人群更广泛，更大，因此，目前正在接受低温治疗的患者更具代表性。

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