Is (your cellular response to) stress killing you?

Sierra F

首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Is (your cellular response to) stress killing you?

【24h】

Is (your cellular response to) stress killing you?

机译：（您对细胞的反应）压力会杀死您吗？

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Free radicals provide a generally accepted explanation for age-related decline in tissue function. However, the free radical hypothesis does not provide a mechanistic course of action to explain exactly how damage to macromolecules translates into the recognizable pathophysiology of aged organisms. Recent advances in the fields of DNA damage and cellular senescence point towards a substantial role for the DNA damage response, rather than DNA mutations per se, in the genesis of cellular and/or tissue damage. Furthermore, several studies suggest that protein damage can be at least as important as DNA damage in bringing about the aging phenotype. Here we propose that a "protein damage response," namely the ER/UPR (endoplasmic reticulum/unfolded protein) stress response is likely to play an important role in the aging process.

机译：自由基为年龄相关的组织功能下降提供了公认的解释。但是，自由基假说并未提供机制的作用机理来确切解释大分子的损害如何转化为衰老生物体的可识别病理生理。 DNA损伤和细胞衰老领域的最新进展表明，在细胞和/或组织损伤的发生中，DNA损伤反应起着重要作用，而不是DNA突变本身。此外，一些研究表明，蛋白质损伤在引起衰老表型方面至少与DNA损伤一样重要。在这里，我们提出“蛋白质损伤反应”，即ER / UPR（内质网/未折叠蛋白）应激反应可能在衰老过程中起重要作用。

著录项

来源
《The journals of gerontology.Series A. Biological sciences and medical sciences》 |2006年第6期|共5页
作者
Sierra F;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类内科学;
关键词
Aging; DNA Damage; Stress; 衰老; DNA损伤; 应激;

机译：Aging;DNA Damage;Stress;衰老;DNA损伤;应激;

相似文献

外文文献
中文文献
专利

1. K deficiency caused defects in renal tubular cell proliferation, oxidative stress response, tissue repair and tight junction integrity, but enhanced energy production, proteasome function and cellular K+ uptakeproliferation, oxidative stress response, tissuerepair and tight junction integrity, but enhancedenergy production, proteasome function andcellular+ deficiency caused defects in renal tubular cellproliferation, oxidative stress response, tissuerepair and tight junction integrity, but enhancedenergy production, proteasome function andcellular K+ uptakeK deficiency caused defects in renal tubular cell proliferation, oxidative stress response, tissue repair and tight junction integrity, but enhanced energy production, proteasome function and cellular Ksup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oasis="http://docs.oasis-open.orgs/oasis-exchange/table"+/sup uptake [J] . Chompunoot Kapincharanon, Visith Thongboonkerd Cell adhesion & migration . 2018,第3期

机译：钾缺乏引起肾小管细胞增殖，氧化应激反应，组织修复和紧密连接完整性方面的缺陷，但增强了能量产生，蛋白酶体功能和细胞对K +的吸收，氧化应激反应，组织修复和紧密连接完整性，但增强了能量产生，蛋白酶体功能和细胞+缺乏会导致肾小管细胞增殖，氧化应激反应，组织修复和紧密连接完整性方面的缺陷，但能量产生，蛋白酶体功能和细胞对K +摄取的增加会导致肾小管细胞增殖，氧化应激反应，组织修复和紧密连接完整性方面的缺陷，但能量增加生产，蛋白酶体功能和细胞K ^{+ 吸收}
2. Is (Your Cellular Response to) Stress Killing You? [J] . Felipe Sierra The Journals of Gerontology Series A: Biological Sciences and Medical Sciences . 2006,第6期

机译：（您对细胞的反应）压力会杀死您吗？
3. Potential of Radiation-Induced Cellular Stress for Reactivation of Latent HIV-1 and Killing of Infected Cells [J] . Iordanskiy Sergey, Kashanchi Fatah AIDS Research and Human Retroviruses . 2016,第2期

机译：辐射诱导的细胞应激的潜力，用于再激活潜伏的HIV-1和杀伤感染细胞
4. Imaging the cellular response to transient shear stress using time-resolved digital holography [C] . Yoshihiko Arita, Maciej Antkowiak, Frank Gunn-Moore, Optical Elastography and Tissue Biomechanics . 2014

机译：使用时间分辨数字全息成像对瞬时剪切应力的细胞反应进行成像
5. Expression and Localization Dynamics of The Aging Biomarker P16INK4a in Response to Cellular Stress, Autophagy, and Epigenetic Modulators [D] . Coryell, Philip Richard. 2019

机译：老化生物标志物P16ink4a响应细胞应激，自噬和表观遗传调节剂的表达和定位动态
6. Potential of Radiation-Induced Cellular Stress for Reactivation of Latent HIV-1 and Killing of Infected Cells [O] . Sergey Iordanskiy, Fatah Kashanchi -1

机译：辐射诱导的细胞应激对潜在HIV-1的活化和感染细胞杀伤的潜力
7. Is (Your Cellular Response to) Stress Killing You? [O] . F. Sierra 2006

机译：是（你的蜂窝反应）压力杀了你吗？

Is (your cellular response to) stress killing you?

摘要

著录项

相似文献

相关主题

期刊订阅