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首页> 外文期刊>The American Journal of Cardiology >Comparison of Two-Year Outcomes in Patients Undergoing Isolated Coronary Artery Bypass Grafting With and Without Peripheral Artery Disease
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Comparison of Two-Year Outcomes in Patients Undergoing Isolated Coronary Artery Bypass Grafting With and Without Peripheral Artery Disease

机译：患有和不伴有外周动脉疾病的孤立性冠状动脉旁路移植术患者两年结局的比较

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We aimed to evaluate the long-term clinical outcomes among patients with peripheral arterial disease (PAD) after coronary artery bypass grafting. We studied 589 consecutive patients who had undergone isolated coronary artery bypass grafting from January 2003 to June 2005 at our university hospital. The effect of PAD was assessed by comparing the 2-year follow-up data from 2 groups of patients: 243 patients with and 346 without PAD. A large systematic atherosclerosis screening was performed, including cerebrovascular disease, lower extremity artery disease, and abdominal aorta disease and its branches. PAD was defined as a history of treated atherosclerotic disease and significant atherosclerotic stenosis on screening. Patients with PAD were significantly older (70 +- 9 vs 64 +- 11 years, p < 0.001) and were more often men (p = 0.04) than those without PAD. They had a greater incidence of hypertension (p = 0.002), chronic renal dysfunction (p <0.01), chronic pulmonary disease (p = 0.005), and a history of coronary artery disease (p = 0.03). No significant difference was noted between the 2 groups with regard to the left ventricular ejection fraction. The 2-year cumulative survival rate was 76.6% for patients with PAD and 94.1% for those with isolated coronary disease (p <0.001). In conclusion, after adjusting all significant variables, the presence of PAD appeared as an independent predictive factor for all-cause mortality (adjusted hazard ratio 3.2, 95% confidence interval 1.8 to 5.7, p = 0.001).
机译：我们旨在评估冠状动脉搭桥术后外周动脉疾病（PAD）患者的长期临床结局。从2003年1月至2005年6月，我们在我们的大学医院研究了589例接受了单纯冠状动脉搭桥术的患者。通过比较两组患者的2年随访数据来评估PAD的效果：243例有PAD的患者和346例无PAD的患者。进行了系统的大型动脉粥样硬化检查，包括脑血管疾病，下肢动脉疾病，腹主动脉疾病及其分支。 PAD被定义为治疗过的动脉粥样硬化病史和筛查时明显的动脉粥样硬化狭窄。与没有PAD的患者相比，患有PAD的患者明显年龄更大（70±9岁vs 64±11岁，p <0.001），并且男性的发病率更高（p = 0.04）。他们有较高的高血压发生率（p = 0.002），慢性肾功能不全（p <0.01），慢性肺部疾病（p = 0.005）和冠心病史（p = 0.03）。两组之间在左心室射血分数方面无显着差异。 PAD患者的2年累积生存率为76.6％，单纯性冠心病患者的2年累积生存率为94.1％（p <0.001）。总之，在调整了所有重要变量后，PAD的存在似乎是全因死亡率的独立预测因素（调整后的危险比为3.2，95％置信区间为1.8至5.7，p = 0.001）。

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