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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: a multicenter randomized controlled study.
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The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: a multicenter randomized controlled study.

机译：局部两性霉素B对慢性鼻-鼻窦炎患者炎症标志物的影响：一项多中心随机对照研究。

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BACKGROUND: It has been suggested that an exaggerated immune response to fungi is crucial in the pathogenesis of chronic rhinosinusitis (CRS). Based on this rationale, the use of topical antifungals (amphotericin B) has been advocated. Studies on its clinical effectiveness are, however, contradictory. OBJECTIVES: To examine the effect of nasal antifungal treatment on secreted mediators in samples of nasal lavage fluid from patients with CRS with or without nasal polyps (NP). METHODS: Part two of a prospective double-blind, placebo-controlled multicenter clinical trial investigating the effect of 13 weeks of treatment with amphotericin B or placebo on the levels of pro-inflammatory cytokines, chemokines and growth factors (i.e., IL-1beta, IL-1RA, IL-2, IL-2R, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p40/p70 subunits), IL-13, IL-15, IL-17, TNF-alpha, IFN-alpha, IFN-gamma, G-CSF, GM-CSF, MIP-1alpha, MIP-1beta, IP-10, MIG, eotaxin, RANTES, MCP-1, MCP-2, MCP-3, VEGF, EGF, FGF-basic, HGF, Gro-alpha)and albumin via a fluorescent enzyme immunoassay in nasal lavage specimens of CRS patients with or without NP. RESULTS: Topical amphotericin B had no significant effect on the level of any of the tested pro-inflammatory cytokines, chemokines, and growth factors in CRS nasal lavage samples. Treatment with placebo, however, increased the level of MIP-1alpha and MIP-1beta, which are mediators involved in wound healing. CONCLUSIONS: Topical amphotericin B has no significant effect on activation markers of nasal inflammatory cells in chronic rhinosinusitis with or without nasal polyps.
机译：背景：已经提出，对真菌的过度免疫反应在慢性鼻鼻窦炎（CRS）的发病机理中至关重要。基于此原理，已提倡使用局部抗真菌药（两性霉素B）。然而，关于其临床有效性的研究却是矛盾的。目的：探讨鼻腔抗真菌治疗对患有或不伴有鼻息肉（NP）的CRS患者鼻腔冲洗液样本中分泌型介质的影响。方法：一项前瞻性双盲，安慰剂对照多中心临床试验的第二部分，研究了用两性霉素B或安慰剂治疗13周对促炎性细胞因子，趋化因子和生长因子（即IL-1beta， IL-1RA，IL-2，IL-2R，IL-3，IL-4，IL-5，IL-6，IL-7，IL-8，IL-10，IL-12（p40 / p70亚基）， IL-13，IL-15，IL-17，TNF-alpha，IFN-alpha，IFN-γ，G-CSF，GM-CSF，MIP-1alpha，MIP-1beta，IP-10，MIG，eotaxin，RANTES，在患有或不患有NP的CRS患者的鼻灌洗标本中，通过荧光酶免疫法测定MCP-1，MCP-2，MCP-3，VEGF，EGF，FGF-碱性，HGF，Gro-α和白蛋白。结果：局部两性霉素B对CRS鼻灌洗液样本中任何测试的促炎细胞因子，趋化因子和生长因子的水平均无显着影响。然而，用安慰剂治疗会增加MIP-1alpha和MIP-1beta的水平，这是伤口愈合的中介物。结论：外用两性霉素B对有或无鼻息肉的慢性鼻-鼻窦炎鼻炎细胞活化标志物无显着影响。

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