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首页> 外文期刊>The American Journal of Cardiology >Effect of anemia on short- and long-term outcome in patients hospitalized for acute coronary syndromes
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Effect of anemia on short- and long-term outcome in patients hospitalized for acute coronary syndromes

机译：贫血对急性冠脉综合征住院患者短期和长期预后的影响

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Anemia is common in hospitalized cardiac patients and is associated with adverse outcomes. The aim of this study was to identify the association of anemia with early and long-term outcomes in patients with acute coronary syndromes (ACSs). Included were 5,304 consecutive patients (73% men, 61 ± 12 years of age) admitted to a coronary care unit from 1985 through 2008 for ACS. According to the World Health Organization, anemia was defined as serum hemoglobin levels <13 g/dl for men and <12 g/dl for women. Anemia was divided into tertiles to compare mild, moderate, and severe anemia to nonanemia. For trend analyses the study population was categorized in 3 groups: 1985 to 1990, 1991 to 2000, and 2001 to 2008. Outcome measurements were all-cause mortality at 30-days and 20 years. Anemia was present in 2,016 patients (38%), of whom 655 had mild anemia, 717 moderate anemia, and 646 severe anemia. Median follow-up duration was 10 years (range 2 to 25). Compared to nonanemia, adjusted hazard ratios (HRs) for mortality at 30 days were 1.40 for moderate anemia (95% confidence interval [CI] 1.04 to 1.87) and 1.67 for severe anemia (95% CI 1.25 to 2.24). At 20 years HRs were 1.13 for moderate anemia (95% CI 1.01 to 1.27) and 1.39 for severe anemia (95% CI 1.23 to 1.56). In addition, survival during hospitalization improved over time. Compared to 1985 to 1990 adjusted HRs were 0.52 for 1991 to 2000 (95% CI 0.41 to 0.66) and 0.36 for 2001 to 2008 (95% CI 0.25 to 0.51). In conclusion, presence and severity of anemia is an important predictor of higher in-hospital and long-term mortality after ACS. In addition, since the 1980s in-hospital outcome of patients with ACS and anemia has improved.
机译：贫血常见于住院的心脏病患者，并与不良后果相关。这项研究的目的是确定急性冠脉综合征（ACSs）患者贫血与早期和长期预后的关系。包括从1985年至2008年接受ACS的5304例连续患者（73％的男性，61±12岁）被纳入冠心病监护室。根据世界卫生组织的定义，贫血定义为男性的血红蛋白水平<13 g / dl，女性<12 g / dl。贫血分为三分位数，以比较轻度，中度和重度贫血与非贫血。为了进行趋势分析，研究人群分为3组：1985年至1990年，1991年至2000年以及2001年至2008年。结果测量为30天和20年时的全因死亡率。 2,016例患者（38％）存在贫血，其中655例为轻度贫血，717例中度贫血和646例严重贫血。中位随访时间为10年（范围2至25）。与非贫血相比，中度贫血（95％置信区间[CI] 1.04至1.87）和重度贫血（95％CI 1.25至2.24）的30天死亡率调整后的危险比（HRs）为1.40。在20岁时，中度贫血的HRs为1.13（95％CI 1.01至1.27），而严重贫血的HRs为1.39（95％CI 1.23至1.56）。此外，住院期间的存活率随时间而提高。与1985年至1990年相比，1991年至2000年的调整后HR为0.52（95％CI为0.41至0.66），2001年至2008年为0.36（95％CI为0.25至0.51）。总之，贫血的存在和严重程度是ACS后住院和长期死亡率较高的重要预测指标。此外，自1980年代以来，ACS和贫血患者的院内结局已有所改善。

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