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首页> 外文期刊>The Journal of Experimental Biology >Muscle fibre size optimisation provides flexibility for energy budgeting in calorie-restricted coho salmon transgenic for growth hormone
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Muscle fibre size optimisation provides flexibility for energy budgeting in calorie-restricted coho salmon transgenic for growth hormone

机译：肌肉纤维尺寸的优化为限制卡路里的转基因鲑鱼生长激素的能量预算提供了灵活性

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摘要

Coho salmon (Oncorhynchus kisutch) transgenic for growth hormone (GH) show substantially faster growth than wild-type (WT) fish. We fed GH-transgenic salmon either to satiation (1 year; TF) or the same smaller ration of wild-type fish (2 years; TR), resulting in groups matched for body size to WT salmon. The myotomes of TF and WT fish had the same number and size distribution of muscle fibres, indicating a twofold higher rate of fibre recruitment in the GH transgenics. Unexpectedly, calorie restriction was found to decrease the rate of fibre production in transgenics, resulting in a 20% increase in average fibre size and reduced costs of ionic homeostasis. Genes for myotube formation were downregulated in TR relative to TF and WT fish. We suggest that muscle fibre size optimisation allows the reallocation of energy from maintenance to locomotion, explaining the observation that calorie-restricted transgenics grow at the same rate as WT fish whilst exhibiting markedly higher foraging activity
机译：转基因生长激素（GH）的银鲑（Oncorhynchus kisutch）的生长速度明显快于野生型（WT）鱼。我们以饱食（1年; TF）或相同比例的野生型鱼（2年; TR）喂养GH转基因鲑鱼，导致其体型与野生鲑匹配。 TF和WT鱼的肌肉组织具有相同数量和大小的肌纤维分布，这表明GH转基因中的纤维募集率高出两倍。出乎意料的是，发现热量限制会降低转基因动物中纤维的产生速率，从而使平均纤维大小增加20％，并降低离子稳态的成本。相对于TF和WT鱼，TR中的肌管形成基因被下调。我们认为，肌肉纤维大小的优化可以使能量从维持到运动再分配，这解释了以下观察结果：受卡路里限制的转基因以与野生型鱼类相同的速度生长，同时表现出明显更高的觅食活动

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