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首页> 外文期刊>Therapeutic apheresis and dialysis: official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy >Occult Hepatitis B Virus Infection in Hemodialysis Patients in Japan
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Occult Hepatitis B Virus Infection in Hemodialysis Patients in Japan

机译：日本血液透析患者的隐匿性乙型肝炎病毒感染

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Hepatitis B surface antigen is widely used in hepatitis B virus surveillance; patients who test negative for the antigen are judged to be uninfected. However, occult hepatitis B virus infection has been confirmed with hepatitis B virus DNA at low levels in the liver and peripheral blood in patients positive for hepatitis B core antibody or hepatitis B surface antibody, even if they test negative for hepatitis B surface antigen. To investigate the prevalence of occult hepatitis B virus in hemodialysis patients, we performed cross-sectional analysis of 161 hemodialysis patients in two related institutions for hepatitis B surface antigen, hepatitis B core antibody, and hepatitis B surface antibody. Hepatitis B surface antigen, hepatitis B core antibody, or hepatitis B surface antibody was present in 45 patients (28.0%). Hepatitis B virus DNA was present in six patients (3.7%), all of whom also tested positive for hepatitis B core antibody. Hepatitis B surface antibody positivity was unrelated in only one of the six patients. Four of the six patients were positive for hepatitis B surface antigen; however, two (1.3%) of these with occult hepatitis B virus infection were found to be hepatitis B surface antigen negative. Occult hepatitis B virus infection may be missed in hepatitis B virus surveillance using hepatitis B surface antigen alone; therefore, routine hepatitis B core antibody screening is necessary. Patients who test positive for hepatitis B core antibody should undergo further hepatitis B virus DNA testing to enable accurate hepatitis B virus screening.
机译：乙肝表面抗原广泛用于乙肝病毒监测;抗原测试阴性的患者被判定为未感染。然而，即使对乙型肝炎核心抗体或乙型肝炎表面抗体呈阳性反应的患者，也已证实其隐匿性乙型肝炎病毒感染是由乙型肝炎核心抗体或乙型肝炎表面抗体阳性的患者在肝脏和外周血中以低水平的乙型肝炎病毒DNA确诊的。为了调查血液透析患者中​​隐匿性乙型肝炎病毒的患病率，我们在两个相关机构中对161名血液透析患者进行了横断面分析，涉及乙型肝炎表面抗原，乙型肝炎核心抗体和乙型肝炎表面抗体。乙型肝炎表面抗原，乙型肝炎核心抗体或乙型肝炎表面抗体存在于45例患者中（28.0％）。六名患者（3.7％）中存在乙型肝炎病毒DNA，所有这些患者的乙型肝炎核心抗体检测均呈阳性。乙肝表面抗体阳性与六例患者中只有一例无关。六名患者中有四名乙型肝炎表面抗原阳性。但是，其中有两个（1.3％）隐匿性乙型肝炎病毒感染被发现为乙型肝炎表面抗原阴性。仅使用乙型肝炎表面抗原进行乙型肝炎病毒监测时可能会漏诊隐匿性乙型肝炎病毒;因此，常规的乙肝核心抗体筛查是必要的。乙型肝炎核心抗体检测呈阳性的患者应接受进一步的乙型肝炎病毒DNA检测，以进行准确的乙型肝炎病毒筛查。

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