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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >The development and validation of a risk score for household infestation by Triatoma infestans, a Bolivian vector of Chagas disease
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The development and validation of a risk score for household infestation by Triatoma infestans, a Bolivian vector of Chagas disease

机译：玻利维亚恰加斯病媒介Triatoma infestans的家庭侵染风险评分的开发和验证

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摘要

Chagas disease, primarily spread in Bolivia by the vector Triatoma Infestans, persists as an important public health problem. Preventative insecticide campaigns target spraying on the basis of anecdotal evidence and there is a need for an accurate classification score to correctly identify 'at risk' houses.Data were collected from 337 households on 11 variables through the use of a standardised questionnaire and survey. Risk factors for infestation were identified and a risk score was developed and validated on a separate cohort of 165 houses.Five significant risk factors were identified: cracks in the walls of houses; adobe walls; junk in the peridomiciliary area; no insecticide spraying in the previous two years; and freely ranging animals. A risk score was generated and then calculated for each house. Three risk categories were defined: low, medium and high risk. In the development cohort the infestation rates were 2%, 18% and 69% respectively. The corresponding infestation rates in the validation cohort were 7%, 30% and 75% respectively. Sensitivity and specificity for this test were 81% and 84% and the positive predictive and negative predictive values were 71% and 90%.The risk score developed could be used to inform decision making in underfunded multilateral preventative initiatives.
机译：南美锥虫病主要通过媒介Triatoma Infestans在玻利维亚传播，作为一个重要的公共卫生问题仍然存在。预防性杀虫运动的目标是根据轶事证据进行喷洒，因此需要准确的分类评分以正确识别“有危险”的房屋。通过使用标准化问卷和调查从337个家庭中收集了11个变量的数据。确定了侵扰的风险因素，并在另外165个房屋的队列中开发并验证了风险评分。确定了五个重要的风险因素：房屋墙壁裂缝;土坯墙;周边地区的垃圾;前两年没有喷洒杀虫剂;和自由放养的动物生成风险评分，然后为每个房屋计算。定义了三种风险类别：低，中和高风险。在发展队列中，感染率分别为2％，18％和69％。验证队列中相应的感染率分别为7％，30％和75％。该测试的敏感性和特异性分别为81％和84％，阳性预测值和阴性预测值分别为71％和90％。所建立的风险评分可用于为资金不足的多边预防措施提供决策依据。

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