Homologous recombination: ends as the means

Ray A; Langer M

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Homologous recombination: ends as the means

机译：同源重组：以手段为终点

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Broken chromosomal ends in somatic cells of higher plants frequently heal by the ligation of DNA ends to unrelated sequences or to sequences with micro-homologies. This pathway of DNA-strand-break repair is the bane of gene-targeting attempts in plants. However, there is a second somatic pathway of chromosome repair, which is driven by DNA-sequence homology. Observations from yeast, fly and plants of homologous-recombination mechanisms point towards new strategies of gene targeting in plants.

机译：在高等植物的体细胞中，断裂的染色体末端经常通过DNA末端与无关序列或具有微观同源性的序列的连接而治愈。 DNA链断裂修复的这种途径是植物中基因靶向尝试的祸根。但是，还有第二条染色体修复的体细胞途径，这是由DNA序列同源性驱动的。来自酵母，果蝇和植物的同源重组机制的观察指向了植物中基因靶向的新策略。

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《Trends in Plant Science》 |2002年第10期|共6页
作者
Ray A; Langer M;
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原文格式 PDF
正文语种 eng
中图分类植物学;
关键词
Double-strand breaks; Somatic plant-cells; Induced gap repair; Saccharomyces-cerevisiae; Mitotic recombination; Nonhomologous; recombination; Meiotic recombination; Arabidopsis-thaliana; Targeted; disruption; Dna;

机译：双链断裂;体细胞;诱导间隙修复;酿酒酵母;有丝分裂重组;非同源;重组;减数分裂重组;拟南芥;靶向;破坏;Dna;

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1. Excess Pol???? functions in response to replicative stress in homologous recombination-proficient cancer cells Excess Pol???? functions in response to replicative stress in homologous recombination-proficient cancer cells Excess Pol???? functions in response to replicative stress in homologous recombination-proficient cancer cells [J] . T. Goullet de Rugy, M. Bashkurov, C. Cazaux, Biology Open . 2016,第10期

机译：多余的Pol ???功能在同源重组的癌细胞中对复制压力的反应功能在同源重组的癌细胞中对复制压力的反应同源重组的癌细胞对复制压力的反应
2. Mutagenesis and homologous recombination in Drosophila cell lines using CRISPR/Cas9 Mutagenesis and homologous recombination in Drosophila cell lines using CRISPR/Cas9 Mutagenesis and homologous recombination in Drosophila cell lines using CRISPR/Cas9 [J] . Chris P. Ponting, Charlotte Tibbit, Andrew R. Bassett, Biology Open . 2014,第1期

机译：使用CRISPR / Cas9的果蝇细胞系的诱变和同源重组使用CRISPR / Cas9的果蝇细胞系的诱变和同源重组使用CRISPR / Cas9的果蝇细胞系的诱变和同源重组。
3. 318?Olaparib plus pembrolizumab in patients with previously treated advanced solid tumors with homologous recombination repair mutation and/or homologous recombination repair deficiency: KEYLYNK-007 [J] . Timothy A Yap, Mallika Dhawan, Andrew E Hendifar, Journal for ImmunoTherapy of Cancer . 2020,第Suppla3期

机译：318？Olaparib Plus Pembrolizumab患者以前治疗的先进固体肿瘤，具有同源重组修复突变和/或同源重组修复缺陷：KEYLYNK-007
4. Role of DNA Homologous Recombination and Non-homologous End-Joining in the Maintenance of Chromosomal Integrity [C] . Masao S. Sasaki, Ejichiro Sonoda, Minoru Takata, International congress of radiation research . 2000

机译：DNA同源重组的作用和非同源终端接合在维持染色体完整性
5. Timing Is Everything: The Link between Chromosomal Mobility and Homologous Recombination [D] . Joseph, Fraulin. 2021

机译：时间是一切：染色体迁移率和同源重组之间的联系
6. Extensive homologous recombination in classical swine fever virus: A re-evaluation of homologous recombination events in the strain AF407339 [O] . Youhua Chen, You-Fang Chen 2014

机译：猪瘟病毒中广泛的同源重组：AF407339菌株中同源重组事件的重新评估
7. The Mitochondrial DNA (mtDNA)-Associated Protein SWIB5 Influences mtDNA Architecture and Homologous Recombination. : The Mitochondrial DNA (mtDNA)-Associated Protein SWIB5 Influences mtDNA Architecture and Homologous Recombination. [O] . Blomme, Jonas, Van Aken, Olivier, Van Leene, Jelle, 2017

机译：线粒体DNA（mtDNA）相关蛋白SWIB5影响mtDNA结构和同源重组。：线粒体DNA（mtDNA）相关蛋白SWIB5影响mtDNA的结构和同源重组。

Homologous recombination: ends as the means

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