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Integration of Innate Immune Signaling

机译:先天免疫信号的整合

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摘要

The last decades of research in innate immunology have revealed a multitude of sensing receptors that evaluate the presence of microorganisms or cellular damage in tissues. In the context of a complex tissue, many such sensing events occur simultaneously. Thus, the downstream pathways need to be integrated to launch an appropriate cellular response, to tailor the magnitude of the reaction to the inciting event, and to terminate it in a manner that avoids immunopathology. Here, we provide a conceptual overview of the crosstalk between innate immune receptors in the initiation of a concerted immune reaction to microbial and endogenous triggers. We classify the known interactions into categories of communication and provide examples of their importance in pathogenic infection.
机译:在先天免疫学上的最后几十年的研究表明,许多传感受体可以评估组织中微生物的存在或细胞损伤。在复杂组织的情况下,许多这样的感测事件同时发生。因此,需要整合下游途径,以启动适当的细胞反应,调整针对刺激事件的反应强度,并以避免免疫病理的方式终止反应。在这里,我们提供了对微生物和内源性触发器的协同免疫反应启动中先天免疫受体之间串扰的概念概述。我们将已知的相互作用分类为交流类别,并提供其在致病性感染中重要性的示例。

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