Basophils as antigen presenting cells.

Maddur MS; Kaveri SV; Bayry J

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Basophils as antigen presenting cells.

机译：嗜碱性粒细胞作为抗原呈递细胞。

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Recent reports demonstrate that basophils act as antigen presenting cells to drive Th2 and IgE responses against protease and protein allergens and helminth parasites. Through MHC class II-dependent cognate interactions with CD4(+) T cells in the context of co-stimulatory molecules, and through secretion of IL-4, IL-13 and thymic stromal lymphopoietin, basophils drive antigen-specific Th2 responses. These results have uncovered previously unknown functions of basophils, and should aid in designing novel therapeutic strategies for asthma and allergic conditions.

机译：最近的报道表明，嗜碱性粒细胞充当抗原呈递细胞，以驱动针对蛋白酶和蛋白质过敏原和蠕虫寄生虫的Th2和IgE反应。通过在共刺激分子的背景下与MHC II类依赖的同源相互作用与CD4（+）T细胞相互作用，并通过分泌IL-4，IL-13和胸腺基质淋巴细胞生成素，嗜碱性粒细胞驱动抗原特异性Th2反应。这些结果揭示了嗜碱性粒细胞以前未知的功能，并应有助于设计哮喘和过敏性疾病的新治疗策略。

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《Trends in immunology》 |2010年第2期|共4页
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Maddur MS; Kaveri SV; Bayry J;
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正文语种 eng
中图分类医学免疫学;
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1. Basophils as T(h)2-inducing antigen-presenting cells. [J] . Yoshimoto T International immunology. . 2010,第7期

机译：嗜碱性粒细胞为诱导T（h）2的抗原呈递细胞。
2. Updates on the surface antigens of basophils: CD16 on basophils of patients with respiratory or insect venom allergy and the rejection of CD203c and CD63 externalization decoupling by bisindolylmaleimides [J] . Heneberg Petr, Riegerova Kamila, Rihova Adela, Clinical and experimental allergy : . 2019,第1期

机译：嗜碱性粒细胞表面抗原的更新：CD16呼吸道或昆虫毒液过敏患者嗜碱性粒细胞，并通过Bisindolylmale酰亚胺抑制CD203C和CD63外化解耦
3. Cysteine protease antigens cleave CD123, the alpha subunit of murine IL-3 receptor, on basophils and suppress IL-3-mediated basophil expansion [J] . Nishikado Hideto, Fujimura Tsutomu, Taka Hikari, Biochemical and Biophysical Research Communications . 2015,第2期

机译：半胱氨酸蛋白酶抗原切割CD123，鼠IL-3受体的α亚基，嗜碱性粒细胞和抑制IL-3介导的嗜碱性粒细胞膨胀
4. EVALUATING THE EFFECT OF FORMULATION ON THE UPTAKE OF A ZIKA SUBUNIT VACCINE CANDIDATE BY ANTIGEN-PRESENTING CELLS. [C] . Xiaoling Li, Jakub Dragun, Peter Laing, Conference on vaccine technology VI . 2018

机译：评估配方对有抗原的细胞摄取寨卡亚候选念珠菌疫苗的影响。
5. Potentiation of the immune response with aluminum-containing adjuvants: I. Distribution of adsorbed antigen in mono-valent and combination vaccines; II. Role of antigen adsorption in antigen internalization by dendritic cells. [D] . Morefield, Garry Lee, Jr. 2003

机译：含铝佐剂增强免疫应答：I.单价和组合疫苗中吸附抗原的分布；二。抗原吸附在树突状细胞的抗原内在化中的作用。
6. Prolonged reduction in basophil counts at cutaneous basophil hypersensitivity reaction sites challenged with antigen. [O] . M Desaules, P W Askenase 1982

机译：抗原挑战的皮肤嗜碱性粒细胞超敏反应位点的嗜碱性粒细胞计数持续减少。
7. Demystification of enigma on antigen presenting cell features of human basophils: data from secondary lymphoid organs : APC features of human basophils from SLO [O] . Stephen-Victor, Emmanuel,, Das, Mrinmoy, Sharma, Meenu, 2017

机译：人嗜碱性粒细胞抗原呈递细胞特征上的谜团解神秘：来自次级淋巴器官的数据：来自SLO的人类嗜碱性粒细胞的APC特征

Basophils as antigen presenting cells.

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