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The power in comparisons

机译：比较的力量

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From the time that microbial genome sequencing and analysis efforts began there has been a strong focus on understanding the biology of bacterial pathogens, those organisms that share our planet's biosphere to our detriment. This comes not only from a desire to improve public health through the development of novel prophylaxes and therapeutics, but also from our innate desire to understand these dysfunctional (from our perspective) biological relationships. The ever-increasing number of genome sequences of pathogens has provided us with enhanced power to use comparative genomic analysis to explore many of the aspects of the host-pathogen relationship from the perspective of the pathogen. The issues that can be addressed in this fashion include genome evolution, genome determinants of host range and environmental survival, and the identification of crucial virulence determinants.
机译：从微生物基因组测序和分析工作开始以来，人们就一直非常重视了解细菌病原体的生物学，这些细菌与我们的星球生物圈共享我们的有害生物。这不仅源于通过开发新的预防剂和治疗剂来改善公共卫生的愿望，还源于我们天生的理解（从我们的角度来看）这些功能失调的生物学关系的渴望。病原体基因组序列的数量不断增加，使我们有能力使用比较基因组分析从病原体的角度探索宿主与病原体关系的许多方面。以这种方式可以解决的问题包括基因组进化，宿主范围和环境生存的基因组决定因素以及关键毒力决定因素的鉴定。

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