首页> 外文期刊>Trends in Microbiology >The emerging NDM carbapenemases
【24h】

The emerging NDM carbapenemases

机译:新兴的NDM碳青霉烯酶

获取原文
获取原文并翻译 | 示例
           

摘要

Carbapenems were the last beta-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-beta-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 have been reported worldwide, mostly in bacteria from patients epidemiologically linked to the Indian subcontinent, where they occur widely in hospital and community infections, and also in contaminated urban water. The main type is NDM-1, but minor variants occur. NDM enzymes are present largely in Enterobacteriaceae, but also in non-fermenters and Vibrionaceae. Dissemination predominantly involves transfer of the bla(NDM-1), gene among promiscuous plasmids and clonal outbreaks. Bacteria with NDM-1 are typically resistant to nearly all antibiotics, and reliable detection and surveillance are crucial.
机译:碳青霉烯类是最后的β-内酰胺类,保留了近乎普遍的抗革兰氏阴性活性,但碳青霉烯酶正在传播,并具有抗药性。新德里金属-β-内酰胺酶(NDM)酶是最新被认可的碳青霉烯酶,自2008年以来,全世界已有报道,主要是与印度次大陆流行病学相关的患者细菌,在医院和社区感染中广泛存在,并且在受污染的城市水中。主要类型是NDM-1,但会出现较小的变体。 NDM酶主要存在于肠杆菌科,但也存在于非发酵菌和弧菌科。传播主要涉及bla(NDM-1)基因在混杂质粒之间的克隆和克隆爆发。具有NDM-1的细菌通常对几乎所有抗生素都有抵抗力,因此可靠的检测和监视至关重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号